Identification of anti-Parkinson’s Disease Lead Compounds from Aspergillus ochraceus Targeting Adenosin Receptors A(2A)

Identification of anti-Parkinson’s Disease Lead Compounds from Aspergillus ochraceus Targeting Adenosin Receptors A(2A)
ChemistryOpen. 2021 Jun;10(6):630-638. doi: 10.1002/open.202100022.ABSTRACTTwo novel alkaloids compounds together with fifteen know metabolites were identified from Aspergillus ochraceus. The stereochemistry features of the new molecules were determined via HRESIMS, NMR, ECD, and XRD analyses. Amongst these, compounds two compounds exhibited potential efficacy as anti-Parkinson's disease with the EC50 values of 2.30 and 2.45 μM, respectively. ADMET prediction showed that these ... read more
Source: PubMedPublished on 2021-06-08By Linzhen Hu