Impact of a CD36 inhibitor on Porphyromonas gingivalis mediated atherosclerosis

Impact of a CD36 inhibitor on Porphyromonas gingivalis mediated atherosclerosis
Arch Oral Biol. 2021 Apr 19;126:105129. doi: 10.1016/j.archoralbio.2021.105129. Online ahead of print.ABSTRACTOBJECTIVE: To determine if AP5055 drug, an inhibitor of CD36, prevents the increase in Porphyromonas gingivalis (P. gingivalis) mediated atherosclerosis in low-density lipoprotein receptor knockout (LDLR KO) mice by targeting CD36.METHODS: Male LDLR KO mice were infected with P. gingivalis by oral lavage to induce periodontal disease and fed ... read more
Source: PubMedPublished on 2021-05-02By Umar Rauf Rekhi