Impaired Decision-Making Symptom Significantly Associated in Cerebellar Ataxia – Neurology Live

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• Natural History of Polymerase Gamma-Related Ataxia July 21, 2021 Mov Disord. 2021 Jul 20. doi: 10.1002/mds.28713. Online ahead of print.ABSTRACTBACKGROUND: Mutations in the mitochondrial DNA polymerase gamma are causing a wide phenotypic spectrum including ataxia as one of the most common presentations.OBJECTIVE: The objective of this study was to determine the course of disease of polymerase gamma-related ataxia.METHODS: In a prospective natural history study, we assessed 24 adult ataxia…
• Natural History of Polymerase Gamma-Related Ataxia July 21, 2021 Mov Disord. 2021 Jul 20. doi: 10.1002/mds.28713. Online ahead of print.ABSTRACTBACKGROUND: Mutations in the mitochondrial DNA polymerase gamma are causing a wide phenotypic spectrum including ataxia as one of the most common presentations.OBJECTIVE: The objective of this study was to determine the course of disease of polymerase gamma-related ataxia.METHODS: In a prospective natural history study, we assessed 24 adult ataxia…
• Natural History of Polymerase Gamma-Related Ataxia July 21, 2021 Mov Disord. 2021 Jul 20. doi: 10.1002/mds.28713. Online ahead of print.ABSTRACTBACKGROUND: Mutations in the mitochondrial DNA polymerase gamma are causing a wide phenotypic spectrum including ataxia as one of the most common presentations.OBJECTIVE: The objective of this study was to determine the course of disease of polymerase gamma-related ataxia.METHODS: In a prospective natural history study, we assessed 24 adult ataxia…
• Natural History of Polymerase Gamma-Related Ataxia July 21, 2021 Mov Disord. 2021 Jul 20. doi: 10.1002/mds.28713. Online ahead of print.ABSTRACTBACKGROUND: Mutations in the mitochondrial DNA polymerase gamma are causing a wide phenotypic spectrum including ataxia as one of the most common presentations.OBJECTIVE: The objective of this study was to determine the course of disease of polymerase gamma-related ataxia.METHODS: In a prospective natural history study, we assessed 24 adult ataxia…
• Natural History of Polymerase Gamma-Related Ataxia July 21, 2021 Mov Disord. 2021 Jul 20. doi: 10.1002/mds.28713. Online ahead of print.ABSTRACTBACKGROUND: Mutations in the mitochondrial DNA polymerase gamma are causing a wide phenotypic spectrum including ataxia as one of the most common presentations.OBJECTIVE: The objective of this study was to determine the course of disease of polymerase gamma-related ataxia.METHODS: In a prospective natural history study, we assessed 24 adult ataxia…
• Effect of Deep Brain Stimulation on Cerebellar Tremor Compared to Non-Cerebellar Tremor Using a Wearable Device in a Patient With Multiple Sclerosis: Case Report January 31, 2022 Front Hum Neurosci. 2022 Jan 13;15:754091. doi: 10.3389/fnhum.2021.754091. eCollection 2021.ABSTRACTTremor of the upper extremity is a significant cause of disability in some patients with multiple sclerosis (MS). The MS tremor is complex because it contains an ataxic intentional tremor component due to the involvement of the cerebellum and cerebellar outflow pathways by MS plaques, which makes the MS tremor, in…
• Effect of Deep Brain Stimulation on Cerebellar Tremor Compared to Non-Cerebellar Tremor Using a Wearable Device in a Patient With Multiple Sclerosis: Case Report January 31, 2022 Front Hum Neurosci. 2022 Jan 13;15:754091. doi: 10.3389/fnhum.2021.754091. eCollection 2021.ABSTRACTTremor of the upper extremity is a significant cause of disability in some patients with multiple sclerosis (MS). The MS tremor is complex because it contains an ataxic intentional tremor component due to the involvement of the cerebellum and cerebellar outflow pathways by MS plaques, which makes the MS tremor, in…
• Effect of Deep Brain Stimulation on Cerebellar Tremor Compared to Non-Cerebellar Tremor Using a Wearable Device in a Patient With Multiple Sclerosis: Case Report January 31, 2022 Front Hum Neurosci. 2022 Jan 13;15:754091. doi: 10.3389/fnhum.2021.754091. eCollection 2021.ABSTRACTTremor of the upper extremity is a significant cause of disability in some patients with multiple sclerosis (MS). The MS tremor is complex because it contains an ataxic intentional tremor component due to the involvement of the cerebellum and cerebellar outflow pathways by MS plaques, which makes the MS tremor, in…
• Effect of Deep Brain Stimulation on Cerebellar Tremor Compared to Non-Cerebellar Tremor Using a Wearable Device in a Patient With Multiple Sclerosis: Case Report January 31, 2022 Front Hum Neurosci. 2022 Jan 13;15:754091. doi: 10.3389/fnhum.2021.754091. eCollection 2021.ABSTRACTTremor of the upper extremity is a significant cause of disability in some patients with multiple sclerosis (MS). The MS tremor is complex because it contains an ataxic intentional tremor component due to the involvement of the cerebellum and cerebellar outflow pathways by MS plaques, which makes the MS tremor, in…
• Effect of Deep Brain Stimulation on Cerebellar Tremor Compared to Non-Cerebellar Tremor Using a Wearable Device in a Patient With Multiple Sclerosis: Case Report January 31, 2022 Front Hum Neurosci. 2022 Jan 13;15:754091. doi: 10.3389/fnhum.2021.754091. eCollection 2021.ABSTRACTTremor of the upper extremity is a significant cause of disability in some patients with multiple sclerosis (MS). The MS tremor is complex because it contains an ataxic intentional tremor component due to the involvement of the cerebellum and cerebellar outflow pathways by MS plaques, which makes the MS tremor, in…
• Effect of Deep Brain Stimulation on Cerebellar Tremor Compared to Non-Cerebellar Tremor Using a Wearable Device in a Patient With Multiple Sclerosis: Case Report January 31, 2022 Front Hum Neurosci. 2022 Jan 13;15:754091. doi: 10.3389/fnhum.2021.754091. eCollection 2021.ABSTRACTTremor of the upper extremity is a significant cause of disability in some patients with multiple sclerosis (MS). The MS tremor is complex because it contains an ataxic intentional tremor component due to the involvement of the cerebellum and cerebellar outflow pathways by MS plaques, which makes the MS tremor, in…
• Cerebellar impulsivity-compulsivity assessment scale November 19, 2022 Ann Clin Transl Neurol. 2022 Nov 19. doi: 10.1002/acn3.51698. Online ahead of print.ABSTRACTOBJECTIVE: The cerebellum has been identified as the key brain region that modulates reward processing in animal models. Consistently, we recently found that people with cerebellar ataxia have impulsive and compulsive behaviors (ICBs), the main symptoms related to abnormal reward processing. Due to the lack of a validated…
• Cerebellar impulsivity-compulsivity assessment scale November 19, 2022 Ann Clin Transl Neurol. 2022 Nov 19. doi: 10.1002/acn3.51698. Online ahead of print.ABSTRACTOBJECTIVE: The cerebellum has been identified as the key brain region that modulates reward processing in animal models. Consistently, we recently found that people with cerebellar ataxia have impulsive and compulsive behaviors (ICBs), the main symptoms related to abnormal reward processing. Due to the lack of a validated…
• Cerebellar impulsivity-compulsivity assessment scale November 19, 2022 Ann Clin Transl Neurol. 2022 Nov 19. doi: 10.1002/acn3.51698. Online ahead of print.ABSTRACTOBJECTIVE: The cerebellum has been identified as the key brain region that modulates reward processing in animal models. Consistently, we recently found that people with cerebellar ataxia have impulsive and compulsive behaviors (ICBs), the main symptoms related to abnormal reward processing. Due to the lack of a validated…
• Cerebellar impulsivity-compulsivity assessment scale November 19, 2022 Ann Clin Transl Neurol. 2022 Nov 19. doi: 10.1002/acn3.51698. Online ahead of print.ABSTRACTOBJECTIVE: The cerebellum has been identified as the key brain region that modulates reward processing in animal models. Consistently, we recently found that people with cerebellar ataxia have impulsive and compulsive behaviors (ICBs), the main symptoms related to abnormal reward processing. Due to the lack of a validated…
• Words with Hope December 8, 2021 “There is no medicine like hope, no incentive so great, and no tonic so powerful as expectation of something better tomorrow.” Orison Swett Marden “Hope is a waking dream.” Aristotle Introduction: Over the years, I have used blog posts about a specific word, feeling, or emotion. A frequent word used a lot here is the word ‘hope’. To some, hope may…
• Monthly Research Review: January 2022 January 31, 2022 # # # # At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during January 2022. The post is divided into 10 parts based on the type of research: Top 6 pieces of Parkinson’s news Articles of general interest Basic biology…
• Evaluation of Cerebellar Ataxic Patients November 18, 2022 Neurol Clin. 2023 Feb;41(1):21-44. doi: 10.1016/j.ncl.2022.05.002. Epub 2022 Aug 31.ABSTRACTCerebellar ataxia results from damage to the cerebellum and presents as movement incoordination and variability, gait impairment, and slurred speech. Patients with cerebellar ataxia can also have cognitive and mood changes. Although the identification of causes for cerebellar ataxia can be complex, age of presentation, chronicity, family history, and associated movement…
• Evaluation of Cerebellar Ataxic Patients November 18, 2022 Neurol Clin. 2023 Feb;41(1):21-44. doi: 10.1016/j.ncl.2022.05.002. Epub 2022 Aug 31.ABSTRACTCerebellar ataxia results from damage to the cerebellum and presents as movement incoordination and variability, gait impairment, and slurred speech. Patients with cerebellar ataxia can also have cognitive and mood changes. Although the identification of causes for cerebellar ataxia can be complex, age of presentation, chronicity, family history, and associated movement…
• Evaluation of Cerebellar Ataxic Patients November 18, 2022 Neurol Clin. 2023 Feb;41(1):21-44. doi: 10.1016/j.ncl.2022.05.002. Epub 2022 Aug 31.ABSTRACTCerebellar ataxia results from damage to the cerebellum and presents as movement incoordination and variability, gait impairment, and slurred speech. Patients with cerebellar ataxia can also have cognitive and mood changes. Although the identification of causes for cerebellar ataxia can be complex, age of presentation, chronicity, family history, and associated movement…
• Evaluation of Cerebellar Ataxic Patients November 18, 2022 Neurol Clin. 2023 Feb;41(1):21-44. doi: 10.1016/j.ncl.2022.05.002. Epub 2022 Aug 31.ABSTRACTCerebellar ataxia results from damage to the cerebellum and presents as movement incoordination and variability, gait impairment, and slurred speech. Patients with cerebellar ataxia can also have cognitive and mood changes. Although the identification of causes for cerebellar ataxia can be complex, age of presentation, chronicity, family history, and associated movement…
• Evaluation of Cerebellar Ataxic Patients November 18, 2022 Neurol Clin. 2023 Feb;41(1):21-44. doi: 10.1016/j.ncl.2022.05.002. Epub 2022 Aug 31.ABSTRACTCerebellar ataxia results from damage to the cerebellum and presents as movement incoordination and variability, gait impairment, and slurred speech. Patients with cerebellar ataxia can also have cognitive and mood changes. Although the identification of causes for cerebellar ataxia can be complex, age of presentation, chronicity, family history, and associated movement…