Source: Google NewsPublished on 2021-02-17
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- Ending Par(aquat)-kinson’s November 8, 2020 # # # # Today’s post is an open letter to Jacinda Ardern – Prime minister of New Zealand. # # # # Dear Jacinda (if I may), Firstly, let me thank you for your actions during your first term as Prime Minister of New Zealand. The empathy and compassion you expressed in the face of tragic events like Christchurch…
- Man’s best friend August 15, 2019 Recently it has been determined that many people with Parkinson’s have a distinct smell. It is a subtle odour that only some individuals with a very sensitive sense of smell can detect (Click here to read a previous SoPD post on this topic). This curious discovery has given rise to a number of interesting research programmes which are trying…
- My Parkinson's Life Style Eating Plan May 11, 2018 I’ve been on the Keto diet, as well as several other Paleo and plant-based diets in hopes they would help my Parkinson’s symptoms. When my wife and I decided to get serious with our eating life style again, we looked at our options and our focus turned back to doing the Dr. Wahl’s version of the Paleo diet which we…
- We CAN end Parkinson’s Disease in the future August 27, 2020 Parkinson’s Disease is not inevitable. Parkinson’s Disease is rather preventable.Ray Dorsey MD Can we prevent Parkinson’s Disease in the future? Dr. Ray Dorsey, one of the co-authors of the book “Ending Parkinson’s Disease“, says that we can. On Sunday, August 23, Dr. Dorsey spoke to our Sunday Mornings with Twitchy Women group on Zoom. He said that the major premise…
- We CAN end Parkinson’s Disease in the future August 27, 2020 Parkinson’s Disease is not inevitable. Parkinson’s Disease is rather preventable.Ray Dorsey MD Can we prevent Parkinson’s Disease in the future? Dr. Ray Dorsey, one of the co-authors of the book “Ending Parkinson’s Disease“, says that we can. On Sunday, August 23, Dr. Dorsey spoke to our Sunday Mornings with Twitchy Women group on Zoom. He said that the major premise…
- Low Doses of Herbicide and Lectins Led to Parkinsonism in Animals, Study Reports December 7, 2018 Ingesting a once widely used herbicide called paraquat along with lectins — proteins in common foods that bind carbohydrates (e.g., sugars) — can lead to symptoms typical of Parkinson’s disease and known as parkinsonism, a study reported. Importantly, this animal research provides a new preclinical model for testing treatments in forms of Parkinson’s disease influenced by environmental factors. The study, “Ingestion…
- Low-level Exposure to Pesticides Damages Cells in Ways That Might Lead to Parkinson’s, Study Reports May 31, 2018 Even low-level exposure to certain pesticides disrupts cells in a way that mimics the effects of mutations linked Parkinson’s disease — raising a likelihood of the disease developing in people predisposed to it, a new study reports. These findings may also explain why people living near agricultural areas are seen to be at greater risk of developing Parkinson’s, leading the study’s researchers…
- Early Postnatal Exposure to Paraquat and Maneb in Mice Increases Nigrostriatal Dopaminergic Susceptibility to a Re-challenge with the Same Pesticides at Adulthood: Implications for Parkinson's Disease. August 20, 2019 Related ArticlesEarly Postnatal Exposure to Paraquat and Maneb in Mice Increases Nigrostriatal Dopaminergic Susceptibility to a Re-challenge with the Same Pesticides at Adulthood: Implications for Parkinson's Disease. Neurotox Res. 2019 Aug 17;: Authors: Colle D, Santos DB, Naime AA, Gonçalves CL, Ghizoni H, Hort MA, Farina M Abstract Exposure to environmental contaminants represents an important etiological factor in sporadic Parkinson's…
- Ask the expert: Can environmental factors cause Parkinson’s? June 11, 2020 In the latest in our ‘Ask the expert’ series, neurologist Dr Ray Dorsey discusses how “the rise of Parkinson’s may be largely human-made”, the risk of certain pesticides – and why he thinks activism is crucial to changing the course of the condition How are environmental factors linked to Parkinson’s? The rise of Parkinson’s may be largely human-made. The condition…
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- Ask the expert: Can environmental factors cause Parkinson’s? June 11, 2020 In the latest in our ‘Ask the expert’ series, neurologist Dr Ray Dorsey discusses how “the rise of Parkinson’s may be largely human-made”, the risk of certain pesticides – and why he thinks activism is crucial to changing the course of the condition How are environmental factors linked to Parkinson’s? The rise of Parkinson’s may be largely human-made. The condition…
- Ask the expert: Can environmental factors cause Parkinson’s? June 11, 2020 In the latest in our ‘Ask the expert’ series, neurologist Dr Ray Dorsey discusses how “the rise of Parkinson’s may be largely human-made”, the risk of certain pesticides – and why he thinks activism is crucial to changing the course of the condition How are environmental factors linked to Parkinson’s? The rise of Parkinson’s may be largely human-made. The condition…
- Paraquat Inhalation, a Translationally Relevant Route of Exposure: Disposition to the Brain and Male-Specific Olfactory Impairment in Mice. December 30, 2020 Related ArticlesParaquat Inhalation, a Translationally Relevant Route of Exposure: Disposition to the Brain and Male-Specific Olfactory Impairment in Mice. Toxicol Sci. 2020 Dec 29;: Authors: Anderson T, Merrill AK, Eckard ML, Marvin E, Conrad K, Welle K, Oberdörster G, Sobolewski M, Cory-Slechta DA Abstract Epidemiological and experimental studies have associated oral and systemic exposures to the herbicide paraquat (PQ) with…
- Researchers Unravel Link Between Herbicide Exposure and Parkinson’s October 27, 2017 After exposure to the herbicide paraquat, genes that may lead to Parkinson’s disease were identified using an innovative gene-editing technique. The study, “A CRISPR screen identifies a pathway required for paraquat-induced cell death,” was published in Nature Chemical Biology. Exposure to the herbicide paraquat is associated with Parkinson’s. Paraquat kills cells through a mechanism called oxidative stress, but how this…
- Scientist Lands $5M Grant to Study Link Between Pesticides, Smell and Parkinson’s March 8, 2019 The National Institutes of Health (NIH) has granted a Michigan State University scientist $5 million to study a possible link between pesticides, a diminished sense of smell, and early symptoms of diseases such as Parkinson’s among older farmers. The investigator is Honglei Chen, MD, PhD, a professor of epidemiology whose research focuses on neurodegenerative disorders. His primary scientific interests include environmental and…
- Taste, Smell Impairments May Help Identify People at Risk for Parkinson’s, Study Suggests December 5, 2018 Impaired sense of smell or taste can raise a person’s risk of developing Parkinson’s disease 2.5 times, a study suggests. The study, “Incidence of Parkinson’s disease in a large patient cohort with idiopathic smell and taste loss,” was published in the Journal of Neurology. Currently, Parkinson’s disease is diagnosed mainly on the assessment of patients’ motor symptoms and their severity. However, evaluation…
- Monthly Research Review – November 2020 November 30, 2020 At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during November 2020. The post is divided into seven parts based on the type of research: Basic biology Disease mechanism Clinical research New clinical trials Clinical trial news Conferences/lectures Other news…
- Researchers Breathing Easier as Smell Tests May Diagnose Parkinson’s Earlier October 25, 2017 Two new tests that diagnose smell dysfunction are an effective method to detect Alzheimer’s and Parkinson’s diseases across different patient populations, a study shows. The study, “SMELL-S and SMELL-R: Olfactory tests not influenced by odor-specific insensitivity or prior olfactory experience,” was published in the journal PNAS. Smell dysfunction is a common medical disorder that tends to be under-diagnosed, but can…
- Leucine-rich repeat kinase-2 (LRRK2) modulates paraquat-induced inflammatory sickness and stress phenotype. June 9, 2019 Related ArticlesLeucine-rich repeat kinase-2 (LRRK2) modulates paraquat-induced inflammatory sickness and stress phenotype. J Neuroinflammation. 2019 Jun 07;16(1):120 Authors: Rudyk C, Dwyer Z, Hayley S, CLINT membership Abstract BACKGROUND: Leucine-rich repeat kinase 2 (LRRK2) is a common gene implicated in Parkinson's disease (PD) and is also thought to be fundamentally involved in numerous immune functions. Thus, we assessed the role of…
- Characterizing the protracted neurobiological and neuroanatomical effects of paraquat in a murine model of Parkinson's disease. January 16, 2021 Related ArticlesCharacterizing the protracted neurobiological and neuroanatomical effects of paraquat in a murine model of Parkinson's disease. Neurobiol Aging. 2020 Nov 26;100:11-21 Authors: Dwyer Z, Rudyk C, Farmer K, Beauchamp S, Shail P, Derksen A, Fortin T, Ventura K, Torres C, Ayoub K, Hayley S Abstract The primary motor symptoms of Parkinson's disease (PD) result from the degeneration of dopamine-producing…
- Lesion of the locus coeruleus damages learning and memory performance in paraquat and maneb-induced mouse Parkinson's disease model. October 22, 2019 Lesion of the locus coeruleus damages learning and memory performance in paraquat and maneb-induced mouse Parkinson's disease model. Neuroscience. 2019 Oct 18;: Authors: Hou L, Sun F, Sun W, Zhang L, Wang Q Abstract The damage of locus coeruleus (LC) noradrenergic neurons and associated with norepinephrine (NE) depletion are early events in Parkinson's disease (PD). Previous study showed that LC/NE…
- Chronic unpredictable stress influenced the behavioral but not the neurodegenerative impact of paraquat. July 16, 2019 Chronic unpredictable stress influenced the behavioral but not the neurodegenerative impact of paraquat. Neurobiol Stress. 2019 Nov;11:100179 Authors: Rudyk C, Dwyer Z, McNeill J, Salmaso N, Farmer K, Prowse N, Hayley S Abstract The impact of psychological stressors on the progression of motor and non-motor disturbances observed in Parkinson's disease (PD) has received little attention. Given that PD likely results…