In Parkinson’s patient-derived dopamine neurons, the triplication of alpha-synuclein locus induces distinctive firing pattern by impeding D2 receptor autoinhibition

In Parkinson’s patient-derived dopamine neurons, the triplication of alpha-synuclein locus induces distinctive firing pattern by impeding D2 receptor autoinhibition
Acta Neuropathol Commun. 2021 Jun 7;9(1):107. doi: 10.1186/s40478-021-01203-9.ABSTRACTPathophysiological changes in dopamine neurons precede their demise and contribute to the early phases of Parkinson's disease (PD). Intracellular pathological inclusions of the protein α-synuclein within dopaminergic neurons are a cardinal feature of PD, but the mechanisms by which α-synuclein contributes to dopaminergic neuron vulnerability remain unknown. The inaccessibility to diseased tissue has ... read more
Source: PubMedPublished on 2021-06-08By Min Lin