In vitro and in vivo neuroprotective effect of novel mPGES-1 inhibitor in animal model of Parkinson’s Disease

In vitro and in vivo neuroprotective effect of novel mPGES-1 inhibitor in animal model of Parkinson’s Disease
Bioorg Med Chem Lett. 2022 Aug 2:128920. doi: 10.1016/j.bmcl.2022.128920. Online ahead of print.ABSTRACTmPGES-1 is found to be up-regulated in the dopaminergic neurons of the substantia nigra pars compacta (SNpc) of postmortem brain tissue from Parkinson's disease (PD) patients and neurotoxin 6-hydroxydopamine (6-OHDA)-induced PD mice. Since the genetic deletion of mPGES-1 abolished 6-OHDA-induced PGE2 production and 6-OHDA-induced dopaminergic neurodegeneration in vitro ... read more
Source: PubMedPublished on 2022-08-05By Seyoung Yang