Increased cysteine metabolism in PINK1 models of Parkinson’s disease

Increased cysteine metabolism in PINK1 models of Parkinson’s disease
Dis Model Mech. 2023 Jan 1;16(1):dmm049727. doi: 10.1242/dmm.049727. Epub 2023 Jan 25.ABSTRACTParkinson's disease (PD), an age-dependent neurodegenerative disease, is characterised by the selective loss of dopaminergic neurons in the substantia nigra (SN). Mitochondrial dysfunction is a hallmark of PD, and mutations in PINK1, a gene necessary for mitochondrial fitness, cause PD. Drosophila melanogaster flies with pink1 mutations exhibit mitochondrial defects ... read more
Source: PubMedPublished on 2023-01-25By Marco Travaglio