Increased phospho-AKT in blood cells from LRRK2 G2019S mutation carriers

Increased phospho-AKT in blood cells from LRRK2 G2019S mutation carriers
Ann Neurol. 2022 Aug 4. doi: 10.1002/ana.26469. Online ahead of print.ABSTRACTTo investigate whether differential phosphorylation states of blood markers can identify LRRK2 Parkinson's disease (PD) patients, we assessed phospho(P)-Ser-935-LRRK2 and P-Ser-473-AKT levels in peripheral blood cells from G2019S LRRK2-associated PD patients (L2PD, n=31), G2019S LRRK2 non-manifesting carriers (L2NMC, n=26), idiopathic PD (iPD, n=25), and controls (n=40) (total n=122). We found ... read more
Source: PubMedPublished on 2022-08-05By Alicia Garrido