Inhibitor and substrate cooperate to inhibit amyloid fibril elongation of α-synuclein

Inhibitor and substrate cooperate to inhibit amyloid fibril elongation of α-synuclein
Chem Sci. 2020 Sep 28;11(41):11331-11337. doi: 10.1039/d0sc04051g.ABSTRACTIn amyloid fibril elongation, soluble growth substrate binds to the fibril-end and converts into the fibril conformation. This process is targeted by inhibitors that block fibril-ends. Here, we investigated how the elongation of α-synuclein (αS) fibrils, which are associated with Parkinson's disease and other synucleinopathies, is inhibited by αS variants with a preformed hairpin ... read more
Source: PubMedPublished on 2021-06-07By Emil Dandanell Agerschou