Interaction of RAGE with α-synuclein fibrils mediates inflammatory response of microglia

Interaction of RAGE with α-synuclein fibrils mediates inflammatory response of microglia
Cell Rep. 2022 Sep 20;40(12):111401. doi: 10.1016/j.celrep.2022.111401.ABSTRACTMicroglia-mediated neuroinflammation and α-synuclein (α-syn) aggregation, both as pathological hallmarks of Parkinson's disease (PD), crosstalk to exacerbate degeneration of dopaminergic neurons and PD progression. However, the mechanism underlying their interaction is poorly understood, which obstructs effective therapeutic inhibition of α-syn-induced neuroinflammation. Here, we initiate from structure-based interaction predictions and find that receptor for advanced ... read more
Source: PubMedPublished on 2022-09-21By Houfang Long