Interactions of COMT and ALDH2 Genetic Polymorphisms on Symptoms of Parkinson’s Disease

Interactions of COMT and ALDH2 Genetic Polymorphisms on Symptoms of Parkinson’s Disease
Brain Sci. 2021 Mar 12;11(3):361. doi: 10.3390/brainsci11030361.ABSTRACT(1) Background: Monoamine neurotransmitters play essential roles in the normal functioning of our nervous system. However, the metabolism of monoamine neurotransmitters is accompanied by the production of neurotoxic metabolites, and inefficient removal of the metabolites has been suggested to cause neurodegeneration. (2) Methods: To examine the effect of reduced activity of catechol-O-methyltransferase (COMT) and ... read more
Source: PubMedPublished on 2021-04-03By Rwei-Ling Yu