Intranasal infusion of GD3 and GM1 gangliosides down-regulates alpha-synuclein and controls tyrosine hydroxylase gene in a PD model mouse

Intranasal infusion of GD3 and GM1 gangliosides down-regulates alpha-synuclein and controls tyrosine hydroxylase gene in a PD model mouse
Mol Ther. 2021 Jun 7:S1525-0016(21)00311-7. doi: 10.1016/j.ymthe.2021.06.005. Online ahead of print.ABSTRACTParkinson's disease (PD) is characterized by Lewy bodies (composed predominantly of alpha-synuclein (aSyn)) and loss of pigmented midbrain dopaminergic neurons comprising the nigrostriatal pathway. Most PD patients show significant deficiency of gangliosides, including GM1, in the brain and GM1 ganglioside appears to keep dopaminergic neurons functioning properly. Thus, supplementation of ... read more
Source: PubMedPublished on 2021-06-10By Yutaka Itokazu