Intronic enhancers of the human SNCA gene predominantly regulate its expression in brain in vivo

Intronic enhancers of the human SNCA gene predominantly regulate its expression in brain in vivo
Sci Adv. 2022 Nov 25;8(47):eabq6324. doi: 10.1126/sciadv.abq6324. Epub 2022 Nov 23.ABSTRACTEvidence from patients with Parkinson's disease (PD) and our previously reported α-synuclein (SNCA) transgenic rat model support the idea that increased SNCA protein is a substantial risk factor of PD pathogenesis. However, little is known about the transcription control of the human SNCA gene in the brain in vivo. Here, ... read more
Source: PubMedPublished on 2022-11-23By Fubo Cheng