Investigating key factors underlying neurodegeneration linked to alpha-synuclein spread

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• The road ahead: 2021 January 25, 2021 # # # # At the start of each year, it is a useful practise to layout what is planned over the next 12 months. The events that are scheduled for the year to come, so that we can keep an eye out for them. Obviously, where 2021 will end actually is unpredictable, but an outline of what is scheduled…
• The road ahead: 2020 January 5, 2020 Here at the SoPD, we are primarily interested in disease modification for Parkinson’s. While there is a great deal of interesting research exploring the causes of the condition, novel symptomatic therapies, and other aspects of Parkinson’s, my focus is generally on the science seeking to slow, stop or reverse the condition. At the start of each year, it is a…
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• Investigating key factors underlying neurodegeneration linked to alpha-synuclein spread June 21, 2022 Neuropathol Appl Neurobiol. 2022 Jun 21:e12829. doi: 10.1111/nan.12829. Online ahead of print.ABSTRACTOBJECTIVES: It has long been considered that accumulation of pathological alpha-synuclein (aSyn) leads to synaptic/neuronal loss which then results in behavioural and cognitive dysfunction. To investigate this claim, we investigated effects downstream of aSyn preformed fibrils (PFF) and 6-hydroxydopamine (6-OHDA), because aSyn PFFs induce spreading/accumulation of aSyn, and 6-OHDA…
• Investigating key factors underlying neurodegeneration linked to alpha-synuclein spread June 21, 2022 Neuropathol Appl Neurobiol. 2022 Jun 21:e12829. doi: 10.1111/nan.12829. Online ahead of print.ABSTRACTOBJECTIVES: It has long been considered that accumulation of pathological alpha-synuclein (aSyn) leads to synaptic/neuronal loss which then results in behavioural and cognitive dysfunction. To investigate this claim, we investigated effects downstream of aSyn preformed fibrils (PFF) and 6-hydroxydopamine (6-OHDA), because aSyn PFFs induce spreading/accumulation of aSyn, and 6-OHDA…
• Investigating key factors underlying neurodegeneration linked to alpha-synuclein spread June 21, 2022 Neuropathol Appl Neurobiol. 2022 Jun 21:e12829. doi: 10.1111/nan.12829. Online ahead of print.ABSTRACTOBJECTIVES: It has long been considered that accumulation of pathological alpha-synuclein (aSyn) leads to synaptic/neuronal loss which then results in behavioural and cognitive dysfunction. To investigate this claim, we investigated effects downstream of aSyn preformed fibrils (PFF) and 6-hydroxydopamine (6-OHDA), because aSyn PFFs induce spreading/accumulation of aSyn, and 6-OHDA…
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