Investigating key factors underlying neurodegeneration linked to alpha-synuclein spread

Investigating key factors underlying neurodegeneration linked to alpha-synuclein spread
Neuropathol Appl Neurobiol. 2022 Jun 21:e12829. doi: 10.1111/nan.12829. Online ahead of print.ABSTRACTOBJECTIVES: It has long been considered that accumulation of pathological alpha-synuclein (aSyn) leads to synaptic/neuronal loss which then results in behavioural and cognitive dysfunction. To investigate this claim, we investigated effects downstream of aSyn preformed fibrils (PFF) and 6-hydroxydopamine (6-OHDA), because aSyn PFFs induce spreading/accumulation of aSyn, and 6-OHDA ... read more
Source: PubMedPublished on 2022-06-21By Cindy C C Pang