Involvement of autophagic protein DEF8 in Lewy bodies

Involvement of autophagic protein DEF8 in Lewy bodies
Biochem Biophys Res Commun. 2022 Jul 20;623:170-175. doi: 10.1016/j.bbrc.2022.07.069. Online ahead of print.ABSTRACTDysregulation of autophagy, one of the major processes through which abnormal proteins are degraded, is a cardinal feature of synucleinopathies, including Lewy body diseases [Parkinson's disease (PD) and dementia with Lewy bodies (DLB)] and multiple system atrophy (MSA), which are characterized by the presence of abnormal α-synuclein in ... read more
Source: PubMedPublished on 2022-08-03By Makoto Timon Tanaka