Source: Google NewsPublished on 2022-06-20
Related Articles:
- IPX203 Extended-Release Capsules Reduce ‘Off’ Time in Advanced Parkinson’s, Trial Shows July 18, 2019 Impax Laboratories‘ investigational carbidopa-levodopa extended-release capsules, IPX203, are better than immediate-release tablets at maintaining steady levels of levodopa in the blood, and prolonging the alleviation of motor symptoms, in people with advanced Parkinson’s disease, according to clinical data. Based on its positive results, the company is now studying IPX203’s safety and effectiveness in people with advanced Parkinson’s in a Phase…
- Pharmacodynamics, Efficacy, and Safety of IPX203 in Parkinson Disease Patients With Motor Fluctuations. July 16, 2019 Pharmacodynamics, Efficacy, and Safety of IPX203 in Parkinson Disease Patients With Motor Fluctuations. Clin Neuropharmacol. 2019 Jul 12;: Authors: Modi NB, Mittur A, Dinh P, Rubens R, Gupta S Abstract OBJECTIVES: IPX203 is an investigational oral extended-release capsule formulation of carbidopa and levodopa. The pharmacodynamics and efficacy of IPX203 were compared with immediate-release carbidopa-levodopa (IR CD-LD) in this open-label, rater-blinded,…
- The many variations of carbidopa/levodopa – the mainstay of Parkinson’s disease treatment March 9, 2021 How carbidopa/levodopa is used to treat Parkinson’s disease symptoms Loss of neurons in the brain that use dopamine to communicate is one of the hallmark features of Parkinson’s disease (PD), causing slowness, stiffness, tremor and balance problems. Replacing the brain’s dopamine is therefore one of the key treatment strategies to help improve the motor symptoms of PD. Dopamine itself does…
- Treating Parkinson’s with Carbidopa/Levodopa November 27, 2020 “If you are always trying to be normal you will never know how amazing you can be.” Maya Angelou “Hope and fear cannot occupy the same space. Invite one to stay.” Maya Angelou Précis: This blog post’s primary goal is to present an overview of Carbidopa/Levodopa (originally named Sinemet) for treating Parkinson’s. A secondary objective was to describe the change in…
- Treating Parkinson’s with Carbidopa/Levodopa November 27, 2020 “If you are always trying to be normal you will never know how amazing you can be.” Maya Angelou “Hope and fear cannot occupy the same space. Invite one to stay.” Maya Angelou Précis: This blog post’s primary goal is to present an overview of Carbidopa/Levodopa (originally named Sinemet) for treating Parkinson’s. A secondary objective was to describe the change in…
- Five Myths About Levodopa March 22, 2022 Levodopa and Parkinson’s Disease When prescribed, levodopa is extremely effective in treating the motor symptoms of Parkinson’s disease (PD) and is embraced by many with PD. Many individuals see using Levodopa as a vital ingredient in maintaining movement and quality of life. It is the most prescribed medication for PD and has been the mainstay of PD treatment for decades.…
- Carbidopa/Levodopa: Answers to the Frequently Asked Questions May 21, 2019 Carbidopa/Levodopa: Answers to the Frequently Asked Questions Loss of neurons in the brain that use dopamine to communicate is one of the hallmark features of Parkinson’s disease (PD), causing slowness, stiffness, tremor and balance problems. Replacing the brain’s dopamine is therefore one of the key treatment strategies to help improve the motor symptoms of PD. Dopamine itself does not cross…
- PD and Medication: What’s New? May 3, 2019 Since its launch in the late 1960s, carbidopa A medication used together with levodopa to enhance its effects. When carbidopa is added to levodopa, the dose of levodopa you take can be smaller while still getting the same benefits, with fewer side effects./levodopaThe medication most commonly given to control the movement symptoms of Parkinson’s, usually with carbidopa. It is converted…
- The road ahead: 2022 January 20, 2022 # # # # The first post at the start of each year on the SoPD website tries to provide an overview of where things are in the search for ‘disease modifying’ therapies for Parkinson’s. It is an exercise in managing expectations as well as discussing what research events are scheduled for the next year so that we can keep…
- Speech, Voice & Parkinson’s Q&A with John Dean January 28, 2021 We recently hosted a webinar with speech-language pathologist John Dean. You can get access to the recording here. We received so many questions during the session that we weren’t able to answer them all; so, John was kind enough to do some written Q&A for us. “When is a good time to start speech therapy?” It’s much better to maintain…
- Infusion Therapies and other Novel Drug Delivery for Parkinson’s disease New Avenues for Old Drugs February 4, 2021 Levodopa – a revolutionary drug with drawbacksAfter more than 50 years since its introduction as a treatment for Parkinson’s disease levodopa still stands out as the most effective of all available drugs when it comes to improving motor symptoms, restoring activities of daily living and maintaining quality of life of people affected by the disease. Although levodopa remains unchallenged as…
- Levodopa dosing and food intake for people with Parkinson’s disease November 2, 2021 The challenges of levodopa dosing and food intake I receive many Ask the Doctor questions about food intake and levodopa ingestion, and I know it’s a tough balance for many. Instructions on how best to take levodopa can seem contradictory. On one hand, people with Parkinson’s disease (PD) are told to separate levodopa from food intake and take their medication…
- Gut Bacteria Ate My Parkinson's Meds June 21, 2019 The dog ate my homework, and gut bacteria ate my Parkinson’s meds. I'm glad it wasn't the other way around. In spite of my poor attempt at humor, this is one of the most interesting scientific discoveries related to Parkinson’s Disease so far this year. No, it does not bring us any closer to a cure, but it is of…
- When sonic hedgehog goes dyskinetic September 24, 2021 # # # # Dyskinesias are involuntary muscle movements associated with long-term use of levodopa therapy (use of levodopa is not a certainty for developing dyskinesias, but there is an association). A better understanding of the underlying biology of dyskinesias is required in order to alleviate this condition for those affected by it. Recently researchers have reported that an imbalance…
- B Vitamins (Folate, B6, B12) Reduce Homocysteine Levels Produced by Carbidopa/Levodopa Therapy September 12, 2017 “The excitement of vitamins, nutrition and metabolism permeated the environment.” Paul D. Boyer “A substance that makes you ill if you don’t eat it.” Albert Szent-Gyorgy Introduction: Claire McLean, an amazing-PT who is vital to my life managing my Parkinson’s, posted a very interesting article about the generation of homocysteine from the metabolism of levodopa to dopamine in the brain.…
- Science Tuesday: Sublingual Carbidopa/Levodopa August 24, 2021 “The human brain doesn’t come with an instruction manual.” Bill Engvall “The great events of the world take place in the brain.” Oscar Wilde Levodopa: Levodopa markedly improves motor symptoms for the majority of people with Parkinson’s. The pharmacological effectiveness of levodopa is quite good; however, it has less efficiency in controlling the non-motor symptoms. When mixed with the enzyme…
- Gut Bacteria Affect Metabolism of Parkinson’s Therapy Levodopa, Study Shows January 24, 2019 Levodopa, one of the main medicines used to treat Parkinson’s symptoms, can be converted into dopamine by gut bacteria, researchers report. The findings might explain why levodopa treatment is less effective in some patients. The study, “Gut bacterial tyrosine decarboxylases restrict levels of levodopa in the treatment of Parkinson’s disease,” was published in Nature Communications. Parkinson’s disease is characterized by…
- Psychosis Treatments October 28, 2019 Psychosis Treatments PSYCHOSIS TREATMENTS Generic Brand Form Indication Adult Initial Dose Adult Dose Titration First-Generation Antipsychotics chlorpromazine HCl — tabs Psychosis. Mania Less acutely disturbed: 25mg three times dailyOutpatient: 10mg 3–4 times daily or 25mg 2–3 times dailySevere cases: 25mg three times daily Inpatient: 500–1000mg/dayLess acutely disturbed: 400mg/dayOutpatient: 200–800mg/day Increase dose gradually until symptoms are controlled. Continue optimum dosage for…
- Low Volume Resistance Training Improves Function in Older People w/ Parkinson's May 3, 2019 Muscle weakness is an almost universal symptom in Parkinson’s Disease. Or is it? This is actually a topic of some debate. People with Parkinson's certainly perceive muscle weakness, which is attributed to low levels of the neurotransmitter dopamine. However you look at it, the motor related symptoms of PD lead to decreased muscle usage, which compounds the problem, resulting in…
- The Science of Parkinson’s OFF November 16, 2020 Although the terms ON and OFF have been used to describe responses to levodopa therapy for more than 40 years, there is still no universally agreed-upon definition for the term OFF, and everyone with Parkinson’s experiences it differently. OFF periods occur when your medication isn’t working optimally, and your motor and non-motor symptoms return. OFF is much more nuanced but understanding its scientific causes…
- The Science of Parkinson’s OFF November 16, 2020 Although the terms ON and OFF have been used to describe responses to levodopa therapy for more than 40 years, there is still no universally agreed-upon definition for the term OFF, and everyone with Parkinson’s experiences it differently. OFF periods occur when your medication isn’t working optimally, and your motor and non-motor symptoms return. OFF is much more nuanced but understanding its scientific causes…
- Parkinson's Disease Medication Overview July 3, 2019 Medications for PD fall into three categories. The first category includes drugs that increase the level of dopamine in the brain. The second category of PD drugs affects other neurotransmitters in the body in order to ease some of the symptoms of the disease. The third category of drugs prescribed for PD includes medications that help control the non-motor symptoms…