Iron buildup in brain can raise risk of movement disorders – study – The Jerusalem Post

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• The road ahead: 2022 January 20, 2022 # # # # The first post at the start of each year on the SoPD website tries to provide an overview of where things are in the search for ‘disease modifying’ therapies for Parkinson’s.  It is an exercise in managing expectations as well as discussing what research events are scheduled for the next year so that we can keep…
• The road ahead: 2021 January 25, 2021 # # # # At the start of each year, it is a useful practise to layout what is planned over the next 12 months. The events that are scheduled for the year to come, so that we can keep an eye out for them. Obviously, where 2021 will end actually is unpredictable, but an outline of what is scheduled…
• The road ahead: 2020 January 5, 2020 Here at the SoPD, we are primarily interested in disease modification for Parkinson’s. While there is a great deal of interesting research exploring the causes of the condition, novel symptomatic therapies, and other aspects of Parkinson’s, my focus is generally on the science seeking to slow, stop or reverse the condition. At the start of each year, it is a…
• L‐DOPA Treatment Prevents Age-related Iron Accumulation, Mouse Study Finds February 14, 2019 Levodopa (L-DOPA) therapy is neuroprotective and prevents age-related iron accumulation in the substantia nigra, a brain region involved in Parkinson’s disease. The study with that finding, “L-DOPA modulates brain iron, dopaminergic neurodegeneration and motor dysfunction in iron overload and mutant alpha-synuclein mouse models of Parkinson’s disease,” was published in the Journal of Neurochemistry. L-DOPA is sill the primary pharmacological treatment for Parkinson’s disease…
• Excess Iron in Brain Cells Worsens Parkinson’s Symptoms, Mouse Study Shows January 9, 2020 While excess iron in the brain often accompanies Parkinson’s disease, it remains unknown whether the iron overload actually causes the neurodegenerative disorder or is merely a product of it. New research now sheds greater light on the role that iron plays in the development of a Parkinson’s disease model. It also illustrates how certain cells regulate the brain’s response to…
• Iron Levels in Brain May Predict Parkinson’s Severity and Cognitive Decline, Study Finds February 25, 2020 Likely cognitive decline, dementia risk, and the severity of motor symptoms in Parkinson’s disease might be tracked by measuring the amount of iron content in the brain, a study reports. These finding were described in the study “Brain iron deposition is linked with cognitive severity in Parkinson’s disease,” published in the Journal of Neurology, Neurosurgery and Psychiatry. The work was developed…
• Iron Levels in Brain May Predict Parkinson’s Severity and Cognitive Decline, Study Finds February 25, 2020 Likely cognitive decline, dementia risk, and the severity of motor symptoms in Parkinson’s disease might be tracked by measuring the amount of iron content in the brain, a study reports. These finding were described in the study “Brain iron deposition is linked with cognitive severity in Parkinson’s disease,” published in the Journal of Neurology, Neurosurgery and Psychiatry. The work was developed…
• Tikvah for Parkinson Breaks Barriers in Jerusalem March 17, 2021 When Debbie Shapiro was diagnosed with Parkinson’s, her doctor’s advice was to take her medications, take it easy, and come back for another appointment in six months. Her response: “No way.”    Instead, she read everything she could about Parkinson’s and what steps she could take to feel her best. She learned, first through literature and then through real-life experience, that…
• Targeting Iron Dyshomeostasis for Treatment of Neurodegenerative Disorders. September 27, 2019 Related ArticlesTargeting Iron Dyshomeostasis for Treatment of Neurodegenerative Disorders. CNS Drugs. 2019 Sep 25;: Authors: Bergsland N, Tavazzi E, Schweser F, Jakimovski D, Hagemeier J, Dwyer MG, Zivadinov R Abstract While iron has an important role in the normal functioning of the brain owing to its involvement in several physiological processes, dyshomeostasis has been found in many neurodegenerative disorders, as…
• Cell specific quantitative iron mapping on brain slices by immuno-PIXE in healthy elderly and Parkinson's disease March 23, 2021 Acta Neuropathol Commun. 2021 Mar 22;9(1):47. doi: 10.1186/s40478-021-01145-2.ABSTRACTIron is essential for neurons and glial cells, playing key roles in neurotransmitter synthesis, energy production and myelination. In contrast, high concentrations of free iron can be detrimental and contribute to neurodegeneration, through promotion of oxidative stress. Particularly in Parkinson's disease (PD) changes in iron concentrations in the substantia nigra (SN) was suggested…
• Cell specific quantitative iron mapping on brain slices by immuno-PIXE in healthy elderly and Parkinson's disease March 23, 2021 Acta Neuropathol Commun. 2021 Mar 22;9(1):47. doi: 10.1186/s40478-021-01145-2.ABSTRACTIron is essential for neurons and glial cells, playing key roles in neurotransmitter synthesis, energy production and myelination. In contrast, high concentrations of free iron can be detrimental and contribute to neurodegeneration, through promotion of oxidative stress. Particularly in Parkinson's disease (PD) changes in iron concentrations in the substantia nigra (SN) was suggested…
• Powerful partnership promotes Parkinson’s rehab in Jerusalem August 24, 2017 Debbie Shapiro founded Tikvah for Parkinson to provide more activities for her local community. By partnering with Israel’s largest volunteer health organisation, she expanded a core offering of physical therapy to a broad mix of sessions including boxing, dance, movement and singing There are more than 10,000 people with Parkinson’s in greater Jerusalem. They need support, information and rehabilitation to…
• A novel treatment strategy to prevent Parkinson's disease: focus on iron regulatory protein 1 (IRP1). February 4, 2021 Related ArticlesA novel treatment strategy to prevent Parkinson's disease: focus on iron regulatory protein 1 (IRP1). Int J Neurosci. 2021 Feb 03;:1-17 Authors: Berry TM, Moustafa AA Abstract We propose that neural damage in Parkinson's disease (PD) is due to dysregulation of iron utilization rather than to high iron levels per se. Iron deposits are associated with neuronal cell death…
• Inflaming the Brain with Iron. January 10, 2021 Related ArticlesInflaming the Brain with Iron. Antioxidants (Basel). 2021 Jan 06;10(1): Authors: Urrutia PJ, Bórquez DA, Núñez MT Abstract Iron accumulation and neuroinflammation are pathological conditions found in several neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD). Iron and inflammation are intertwined in a bidirectional relationship, where iron modifies the inflammatory phenotype of microglia and infiltrating macrophages, and…
• Memory-related Mild Cognitive Impairment May Be Linked to More Severe Alpha-Synuclein Buildup, Researchers Say February 13, 2020 Memory-related mild cognitive impairment in Parkinson’s disease may be associated with a more severe buildup of alpha-synuclein protein in the brain — such as that observed in more advanced stages of the disease, a study finds. The results of the study, “Neuropathological Findings in Parkinson’s Disease With Mild Cognitive Impairment,” were published in Movement Disorders. Studying neuropathological markers — meaning…
• Memory-related Mild Cognitive Impairment May Be Linked to More Severe Alpha-Synuclein Buildup, Researchers Say February 13, 2020 Memory-related mild cognitive impairment in Parkinson’s disease may be associated with a more severe buildup of alpha-synuclein protein in the brain — such as that observed in more advanced stages of the disease, a study finds. The results of the study, “Neuropathological Findings in Parkinson’s Disease With Mild Cognitive Impairment,” were published in Movement Disorders. Studying neuropathological markers — meaning…
• Monthly Research Review – December 2021 December 31, 2021 # # # # At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during December 2021. The post is divided into 10 parts based on the type of research: Top 5 pieces of Parkinson’s news Articles of general interest Basic biology…
• Iron Accumulation in Brain Detected With High-Resolution MRI Technique, Animal Study Shows December 2, 2019 An experimental model of Parkinson’s in non-human primates leads to the accumulation of iron — known to contribute to the underlying causes of the disease — in a brain area linked to motor control. This metal accumulation can be detected using a neuroimaging technique called susceptibility-weighted imaging, according to recent research. The study, titled “The role of iron in Parkinson’s…
• Iron Accumulation in Brain Detected With High-Resolution MRI Technique, Animal Study Shows December 2, 2019 An experimental model of Parkinson’s in non-human primates leads to the accumulation of iron — known to contribute to the underlying causes of the disease — in a brain area linked to motor control. This metal accumulation can be detected using a neuroimaging technique called susceptibility-weighted imaging, according to recent research. The study, titled “The role of iron in Parkinson’s…
• The iron chelator, PBT434, modulates transcellular iron trafficking in brain microvascular endothelial cells July 26, 2021 PLoS One. 2021 Jul 26;16(7):e0254794. doi: 10.1371/journal.pone.0254794. eCollection 2021.ABSTRACTIron and other transition metals, such as copper and manganese, are essential for supporting brain function, yet over-accumulation is cytotoxic. This over-accumulation of metals, particularly iron, is common to several neurological disorders; these include Alzheimer's disease, Parkinson's disease, Friedrich's ataxia and other disorders presenting with neurodegeneration and associated brain iron accumulation. The…
• The iron chelator, PBT434, modulates transcellular iron trafficking in brain microvascular endothelial cells July 26, 2021 PLoS One. 2021 Jul 26;16(7):e0254794. doi: 10.1371/journal.pone.0254794. eCollection 2021.ABSTRACTIron and other transition metals, such as copper and manganese, are essential for supporting brain function, yet over-accumulation is cytotoxic. This over-accumulation of metals, particularly iron, is common to several neurological disorders; these include Alzheimer's disease, Parkinson's disease, Friedrich's ataxia and other disorders presenting with neurodegeneration and associated brain iron accumulation. The…
• The iron chelator, PBT434, modulates transcellular iron trafficking in brain microvascular endothelial cells July 26, 2021 PLoS One. 2021 Jul 26;16(7):e0254794. doi: 10.1371/journal.pone.0254794. eCollection 2021.ABSTRACTIron and other transition metals, such as copper and manganese, are essential for supporting brain function, yet over-accumulation is cytotoxic. This over-accumulation of metals, particularly iron, is common to several neurological disorders; these include Alzheimer's disease, Parkinson's disease, Friedrich's ataxia and other disorders presenting with neurodegeneration and associated brain iron accumulation. The…