Learning critically drives parkinsonian motor deficits through imbalanced striatal pathway recruitment

Learning critically drives parkinsonian motor deficits through imbalanced striatal pathway recruitment
Proc Natl Acad Sci U S A. 2023 Mar 21;120(12):e2213093120. doi: 10.1073/pnas.2213093120. Epub 2023 Mar 15.ABSTRACTDopamine (DA) loss in Parkinson's disease (PD) causes debilitating motor deficits. However, dopamine is also widely linked to reward prediction and learning, and the contribution of dopamine-dependent learning to movements that are impaired in PD-which often do not lead to explicit rewards-is unclear. Here, we ... read more
Source: PubMedPublished on 2023-03-15By Timothy H C Cheung

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