Long non-coding RNA NEAT1 mediates MPTP/MPP(+)-induced apoptosis via regulating the miR-124/KLF4 axis in Parkinson’s disease

Long non-coding RNA NEAT1 mediates MPTP/MPP(+)-induced apoptosis via regulating the miR-124/KLF4 axis in Parkinson’s disease
Open Life Sci. 2020 Sep 6;15(1):665-676. doi: 10.1515/biol-2020-0069. eCollection 2020.ABSTRACTAccumulating evidence suggests that dysregulation of long non-coding RNAs is closely associated with various human diseases, including Parkinson's disease (PD). However, the role of nuclear-enriched abundant transcript 1 (NEAT1) in the PD process remains unclear. The number of TH+ cells was reduced, and the expression levels of NEAT1 and Krüppel-like factor ... read more
Source: PubMedPublished on 2021-04-05By Jiyao Liu