Loss of mitochondrial enzyme GPT2 causes early neurodegeneration in locus coeruleus

Loss of mitochondrial enzyme GPT2 causes early neurodegeneration in locus coeruleus
Neurobiol Dis. 2022 Jul 28:105831. doi: 10.1016/j.nbd.2022.105831. Online ahead of print.ABSTRACTLocus coeruleus (LC) is among the first brain areas to degenerate in Alzheimer's disease and. Parkinson's disease; however, the underlying causes for the vulnerability of LC neurons are not well defined. Here we report a novel mechanism of degeneration of LC neurons caused by loss of the mitochondrial enzyme glutamate ... read more
Source: PubMedPublished on 2022-07-31By Ozan Baytas