Lysosomal K+ channel TMEM175 promotes apoptosis and aggravates symptoms of Parkinson’s disease

Lysosomal K+ channel TMEM175 promotes apoptosis and aggravates symptoms of Parkinson’s disease
EMBO Rep. 2022 Aug 1:e53234. doi: 10.15252/embr.202153234. Online ahead of print.ABSTRACTLysosomes are degradative organelles and play vital roles in a variety of cellular processes. Ion channels on the lysosomal membrane are key regulators of lysosomal function. TMEM175 has been identified as a lysosomal potassium channel, but its modulation and physiological functions remain unclear. Here, we show that the apoptotic regulator ... read more
Source: PubMedPublished on 2022-08-01By Lili Qu