Machine Learning-Based Virtual Screening for the Identification of Cdk5 Inhibitors

Machine Learning-Based Virtual Screening for the Identification of Cdk5 Inhibitors
Int J Mol Sci. 2022 Sep 13;23(18):10653. doi: 10.3390/ijms231810653.ABSTRACTCyclin-dependent kinase 5 (Cdk5) is an atypical proline-directed serine/threonine protein kinase well-characterized for its role in the central nervous system rather than in the cell cycle. Indeed, its dysregulation has been strongly implicated in the progression of synaptic dysfunction and neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD), and ... read more
Source: PubMedPublished on 2022-09-23By Miriana Di Stefano