MALDI–MSI Maps Carboxyls and Aldehydes in Brain Tissue of … – LCGC Chromatography Online

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• On-Tissue Chemical Derivatization for Comprehensive Mapping of Brain Carboxyl and Aldehyde Metabolites by MALDI-MS Imaging April 13, 2023 J Am Soc Mass Spectrom. 2023 Apr 13. doi: 10.1021/jasms.2c00336. Online ahead of print.ABSTRACTThe visualization of small metabolites by MALDI mass spectrometry imaging in brain tissue sections is challenging due to low detection sensitivity and high background interference. We present an on-tissue chemical derivatization MALDI mass spectrometry imaging approach for the comprehensive mapping of carboxyls and aldehydes in brain tissue…
• On-Tissue Chemical Derivatization for Comprehensive Mapping of Brain Carboxyl and Aldehyde Metabolites by MALDI-MS Imaging April 13, 2023 J Am Soc Mass Spectrom. 2023 Apr 13. doi: 10.1021/jasms.2c00336. Online ahead of print.ABSTRACTThe visualization of small metabolites by MALDI mass spectrometry imaging in brain tissue sections is challenging due to low detection sensitivity and high background interference. We present an on-tissue chemical derivatization MALDI mass spectrometry imaging approach for the comprehensive mapping of carboxyls and aldehydes in brain tissue…
• On-Tissue Chemical Derivatization for Comprehensive Mapping of Brain Carboxyl and Aldehyde Metabolites by MALDI-MS Imaging April 13, 2023 J Am Soc Mass Spectrom. 2023 Apr 13. doi: 10.1021/jasms.2c00336. Online ahead of print.ABSTRACTThe visualization of small metabolites by MALDI mass spectrometry imaging in brain tissue sections is challenging due to low detection sensitivity and high background interference. We present an on-tissue chemical derivatization MALDI mass spectrometry imaging approach for the comprehensive mapping of carboxyls and aldehydes in brain tissue…
• On-Tissue Chemical Derivatization for Comprehensive Mapping of Brain Carboxyl and Aldehyde Metabolites by MALDI-MS Imaging April 13, 2023 J Am Soc Mass Spectrom. 2023 Apr 13. doi: 10.1021/jasms.2c00336. Online ahead of print.ABSTRACTThe visualization of small metabolites by MALDI mass spectrometry imaging in brain tissue sections is challenging due to low detection sensitivity and high background interference. We present an on-tissue chemical derivatization MALDI mass spectrometry imaging approach for the comprehensive mapping of carboxyls and aldehydes in brain tissue…
• On-Tissue Chemical Derivatization for Comprehensive Mapping of Brain Carboxyl and Aldehyde Metabolites by MALDI-MS Imaging April 13, 2023 J Am Soc Mass Spectrom. 2023 Apr 13. doi: 10.1021/jasms.2c00336. Online ahead of print.ABSTRACTThe visualization of small metabolites by MALDI mass spectrometry imaging in brain tissue sections is challenging due to low detection sensitivity and high background interference. We present an on-tissue chemical derivatization MALDI mass spectrometry imaging approach for the comprehensive mapping of carboxyls and aldehydes in brain tissue…
• On-Tissue Chemical Derivatization for Comprehensive Mapping of Brain Carboxyl and Aldehyde Metabolites by MALDI-MS Imaging April 13, 2023 J Am Soc Mass Spectrom. 2023 Apr 13. doi: 10.1021/jasms.2c00336. Online ahead of print.ABSTRACTThe visualization of small metabolites by MALDI mass spectrometry imaging in brain tissue sections is challenging due to low detection sensitivity and high background interference. We present an on-tissue chemical derivatization MALDI mass spectrometry imaging approach for the comprehensive mapping of carboxyls and aldehydes in brain tissue…
• Impact of Skin Tissue Collection Method on Downstream MALDI-Imaging June 23, 2022 Metabolites. 2022 May 30;12(6):497. doi: 10.3390/metabo12060497.ABSTRACTMALDI imaging is a novel technique with which to study the pathophysiologies of diseases. Advancements in the field of metabolomics and lipidomics have been instrumental in mapping the signaling pathways involved in various diseases, such as cancer and neurodegenerative diseases (Parkinson's). MALDI imaging is flexible and can handle many sample types. Researchers primarily use either…
• Impact of Skin Tissue Collection Method on Downstream MALDI-Imaging June 23, 2022 Metabolites. 2022 May 30;12(6):497. doi: 10.3390/metabo12060497.ABSTRACTMALDI imaging is a novel technique with which to study the pathophysiologies of diseases. Advancements in the field of metabolomics and lipidomics have been instrumental in mapping the signaling pathways involved in various diseases, such as cancer and neurodegenerative diseases (Parkinson's). MALDI imaging is flexible and can handle many sample types. Researchers primarily use either…
• Recent advances in chemical derivatization-based chromatography-mass spectrometry methods for analysis of aldehyde biomarkers July 2, 2021 Se Pu. 2021 Aug;39(8):845-854. doi: 10.3724/SP.J.1123.2021.02023.ABSTRACTHuman exposure to chemical pollutants in the environment can cause a variety of diseases, including cancer, diabetes, cardiovascular disease, and neurodegenerative diseases (Alzheimer's disease, Parkinson's disease, etc.). Exogenous and environmental pollutant exposure-induced endogenous aldehydes are highly reactive electrophilic compounds that can form covalently modified products with a variety of important biological molecules in the human…
• Recent advances in chemical derivatization-based chromatography-mass spectrometry methods for analysis of aldehyde biomarkers July 2, 2021 Se Pu. 2021 Aug;39(8):845-854. doi: 10.3724/SP.J.1123.2021.02023.ABSTRACTHuman exposure to chemical pollutants in the environment can cause a variety of diseases, including cancer, diabetes, cardiovascular disease, and neurodegenerative diseases (Alzheimer's disease, Parkinson's disease, etc.). Exogenous and environmental pollutant exposure-induced endogenous aldehydes are highly reactive electrophilic compounds that can form covalently modified products with a variety of important biological molecules in the human…
• Recent advances in chemical derivatization-based chromatography-mass spectrometry methods for analysis of aldehyde biomarkers July 2, 2021 Se Pu. 2021 Aug;39(8):845-854. doi: 10.3724/SP.J.1123.2021.02023.ABSTRACTHuman exposure to chemical pollutants in the environment can cause a variety of diseases, including cancer, diabetes, cardiovascular disease, and neurodegenerative diseases (Alzheimer's disease, Parkinson's disease, etc.). Exogenous and environmental pollutant exposure-induced endogenous aldehydes are highly reactive electrophilic compounds that can form covalently modified products with a variety of important biological molecules in the human…
• Recent advances in chemical derivatization-based chromatography-mass spectrometry methods for analysis of aldehyde biomarkers July 2, 2021 Se Pu. 2021 Aug;39(8):845-854. doi: 10.3724/SP.J.1123.2021.02023.ABSTRACTHuman exposure to chemical pollutants in the environment can cause a variety of diseases, including cancer, diabetes, cardiovascular disease, and neurodegenerative diseases (Alzheimer's disease, Parkinson's disease, etc.). Exogenous and environmental pollutant exposure-induced endogenous aldehydes are highly reactive electrophilic compounds that can form covalently modified products with a variety of important biological molecules in the human…
• Recent advances in chemical derivatization-based chromatography-mass spectrometry methods for analysis of aldehyde biomarkers July 2, 2021 Se Pu. 2021 Aug;39(8):845-854. doi: 10.3724/SP.J.1123.2021.02023.ABSTRACTHuman exposure to chemical pollutants in the environment can cause a variety of diseases, including cancer, diabetes, cardiovascular disease, and neurodegenerative diseases (Alzheimer's disease, Parkinson's disease, etc.). Exogenous and environmental pollutant exposure-induced endogenous aldehydes are highly reactive electrophilic compounds that can form covalently modified products with a variety of important biological molecules in the human…
• Recent advances in chemical derivatization-based chromatography-mass spectrometry methods for analysis of aldehyde biomarkers July 2, 2021 Se Pu. 2021 Aug;39(8):845-854. doi: 10.3724/SP.J.1123.2021.02023.ABSTRACTHuman exposure to chemical pollutants in the environment can cause a variety of diseases, including cancer, diabetes, cardiovascular disease, and neurodegenerative diseases (Alzheimer's disease, Parkinson's disease, etc.). Exogenous and environmental pollutant exposure-induced endogenous aldehydes are highly reactive electrophilic compounds that can form covalently modified products with a variety of important biological molecules in the human…
• 3-Acetylpyridine On-Tissue Paternò-Büchi Derivatization Enabling High Coverage Lipid C═C Location-Resolved MS Imaging in Biological Tissues October 26, 2022 Anal Chem. 2022 Oct 26. doi: 10.1021/acs.analchem.2c03089. Online ahead of print.ABSTRACTUnsaturated lipids containing single or more carbon-carbon double bonds (C═C) within tissues are closely associated with various types of diseases. Mass spectrometry imaging (MSI) has been used to study the spatial distribution of lipid C═C location isomers in tissue sections. However, comprehensive characterization of lipid C═C location isomers using MSI…
• 3-Acetylpyridine On-Tissue Paternò-Büchi Derivatization Enabling High Coverage Lipid C═C Location-Resolved MS Imaging in Biological Tissues October 26, 2022 Anal Chem. 2022 Oct 26. doi: 10.1021/acs.analchem.2c03089. Online ahead of print.ABSTRACTUnsaturated lipids containing single or more carbon-carbon double bonds (C═C) within tissues are closely associated with various types of diseases. Mass spectrometry imaging (MSI) has been used to study the spatial distribution of lipid C═C location isomers in tissue sections. However, comprehensive characterization of lipid C═C location isomers using MSI…
• Stratification Strategies for Patients to Optimize the Effectiveness of Scavenging Biogenic Aldehydes: Towards a Neuroprotective Approach for Parkinson's Disease. February 5, 2021 Related ArticlesStratification Strategies for Patients to Optimize the Effectiveness of Scavenging Biogenic Aldehydes: Towards a Neuroprotective Approach for Parkinson's Disease. Curr Neuropharmacol. 2021 Feb 03;: Authors: Masato A, Sandre M, Antonini A, Bubacco L Abstract Parkinson's disease (PD) is a clinically heterogeneous disorder with a multi-factorial pathology. Various molecular mechanisms are involved in the pathogenesis of PD, converging to oxidative…
• Altered prefrontal neurochemistry in the DJ-1 knockout mouse model of Parkinson's disease: complementary semi-quantitative analyses with in vivo magnetic resonance spectroscopy and MALDI-MSI October 8, 2022 Anal Bioanal Chem. 2022 Oct 8. doi: 10.1007/s00216-022-04341-8. Online ahead of print.ABSTRACTIn vivo proton magnetic resonance spectroscopy (1H-MRS) and matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) are two semi-quantitative analytical methods commonly used in neurochemical research. In this study, the two methods were used complementarily, in parallel, to investigate neurochemical perturbations in the medial prefrontal cortex (mPFC) of 9-month-old DJ-1…
• Altered prefrontal neurochemistry in the DJ-1 knockout mouse model of Parkinson's disease: complementary semi-quantitative analyses with in vivo magnetic resonance spectroscopy and MALDI-MSI October 8, 2022 Anal Bioanal Chem. 2022 Oct 8. doi: 10.1007/s00216-022-04341-8. Online ahead of print.ABSTRACTIn vivo proton magnetic resonance spectroscopy (1H-MRS) and matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) are two semi-quantitative analytical methods commonly used in neurochemical research. In this study, the two methods were used complementarily, in parallel, to investigate neurochemical perturbations in the medial prefrontal cortex (mPFC) of 9-month-old DJ-1…
• Altered prefrontal neurochemistry in the DJ-1 knockout mouse model of Parkinson's disease: complementary semi-quantitative analyses with in vivo magnetic resonance spectroscopy and MALDI-MSI October 8, 2022 Anal Bioanal Chem. 2022 Oct 8. doi: 10.1007/s00216-022-04341-8. Online ahead of print.ABSTRACTIn vivo proton magnetic resonance spectroscopy (1H-MRS) and matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) are two semi-quantitative analytical methods commonly used in neurochemical research. In this study, the two methods were used complementarily, in parallel, to investigate neurochemical perturbations in the medial prefrontal cortex (mPFC) of 9-month-old DJ-1…
• The road ahead: 2022 January 20, 2022 # # # # The first post at the start of each year on the SoPD website tries to provide an overview of where things are in the search for ‘disease modifying’ therapies for Parkinson’s.  It is an exercise in managing expectations as well as discussing what research events are scheduled for the next year so that we can keep…
• Increased unsaturated lipids underlie lipid peroxidation in synucleinopathy brain November 15, 2022 Acta Neuropathol Commun. 2022 Nov 14;10(1):165. doi: 10.1186/s40478-022-01469-7.ABSTRACTLipid peroxidation is a process of oxidative degradation of cellular lipids that is increasingly recognized as an important factor in the pathogenesis of neurodegenerative diseases. We were therefore interested in the manifestation of lipid peroxidation in synucleinopathies, a group of neurodegenerative diseases characterized by the central pathology of α-synuclein aggregates, including Parkinson's disease,…