MAPKAPK2, a potential dynamic network biomarker of α-synuclein prior to its aggregation in PD patients

MAPKAPK2, a potential dynamic network biomarker of α-synuclein prior to its aggregation in PD patients
NPJ Parkinsons Dis. 2023 Mar 16;9(1):41. doi: 10.1038/s41531-023-00479-z.ABSTRACTOne of the important pathological features of Parkinson's disease (PD) is the pathological aggregation of α-synuclein (α-Syn) in the substantia nigra. Preventing the aggregation of α-Syn has become a potential strategy for treating PD. However, the molecular mechanism of α-Syn aggregation is unclear. In this study, using the dynamic network biomarker (DNB) method, ... read more
Source: PubMedPublished on 2023-03-17By Zhenggang Zhong