Maturing Autophagosomes are Transported Towards the Cell Periphery

Maturing Autophagosomes are Transported Towards the Cell Periphery
Cell Mol Neurobiol. 2021 Jun 9. doi: 10.1007/s10571-021-01116-0. Online ahead of print.ABSTRACTAutophagosome maturation comprises fusion with lysosomes and acidification. It is a critical step in the degradation of cytosolic protein aggregates that characterize many neurodegenerative diseases. In order to better understand this process, we studied intracellular trafficking of autophagosomes and aggregates of α-synuclein, which characterize Parkinson's disease and other synucleinopathies. ... read more
Source: PubMedPublished on 2021-06-09By Anna Hilverling