Mechanisms of NLRP3 activation and pathology during neurodegeneration

Mechanisms of NLRP3 activation and pathology during neurodegeneration
Int J Biochem Cell Biol. 2022 Aug 1:106273. doi: 10.1016/j.biocel.2022.106273. Online ahead of print.ABSTRACTInflammasomes are multiprotein complexes that are mainly present in resident and infiltrating immune cells in the central nervous system. Inflammasomes function as intracellular sensors of immunometabolic stress, infection and changes in the local microenvironment. Inflammasome assembly in response to these 'danger signals', triggers recruitment and cluster-dependent activation ... read more
Source: PubMedPublished on 2022-08-04By Sara Jose