Source: Google NewsPublished on 2021-01-13
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- The road ahead: 2020 January 5, 2020 Here at the SoPD, we are primarily interested in disease modification for Parkinson’s. While there is a great deal of interesting research exploring the causes of the condition, novel symptomatic therapies, and other aspects of Parkinson’s, my focus is generally on the science seeking to slow, stop or reverse the condition. At the start of each year, it is a…
- Shining a light on Parkinson’s November 7, 2019 NOTE: The information in today’s post should not be considered an endorsement of PhotoPharmics or the treatment they are proposing. The author of this blog has had no communication with the company. The information in this post is provided because the author has been asked by readers to discuss it. In October 2018, at the annual International Movement Disorders…
- Parkinson's Disease News - Editor's Picks (Archive 2016.11) March 17, 2017 Newsfeed: PD News PD Research News PD Fitness News PD Boxing News PD Web Articles PD Blogs PD Editor's Picks PD Twitter Newsfeed Neurons Paralyze Us During REM SleepIt will also be most useful in the study of Parkinson’s disease, since these pathologies are related. This work was published on December 12, 2016 on the website of the journal Brain.…
- 2019: Year in review December 31, 2019 In this end-of-year post, we review the Parkinson’s research that caught our attention at SoPD HQ in 2019. Month-by-month we will briefly discuss some of the major pieces of research/announcements that have defined the year and advanced our understanding of Parkinson’s. The list is based on nothing more than the author’s personal opinion – apologies to any researchers who…
- Monthly research review: February 2020 February 29, 2020 At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during February 2020. The post is divided into seven parts based on the type of research: Basic biology Disease mechanism Clinical research New clinical trials Clinical trial news Other news Review…
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- Monthly research review – October 2019 October 31, 2019 At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during October 2019. The post is divided into seven parts based on the type of research: Basic biology Disease mechanism Clinical research New clinical trials Clinical trial news Other news Review…
- That time APOE met Alpha Syn February 10, 2020 Recently two independent research groups published scientific papers providing evidence that a genetic variation associated with Alzheimer’s may also be affecting the severity of pathology in Parkinson’s. The genetic variation associated with Alzheimer’s occurs in a gene (a functional region of DNA) called ApoE, and the Parkinson’s pathology involves the clustering of a protein called alpha synuclein. Specifically, both…
- Key Parkinson’s Brain Area Implicated in Memory Loss, Study Suggests December 13, 2018 Neurodegeneration in the substantia nigra, a critical area of the brain involved in Parkinson’s, leads to memory deficits, according to a study that explored the effects of levodopa on a rat model of the disease. Findings of the study, titled “Implication of nigral dopaminergic lesion and repeated L-dopa exposure in neuropsychiatric symptoms of Parkinson’s disease,” also illustrated the key role dopamine plays in memory.…
- Monthly Research Review – November 2020 November 30, 2020 At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during November 2020. The post is divided into seven parts based on the type of research: Basic biology Disease mechanism Clinical research New clinical trials Clinical trial news Conferences/lectures Other news…
- Research Roundup: Cognition Changes and Parkinson’s 101 July 26, 2017 If you have Parkinson’s disease (PD), or know someone who does, you likely know that PD affects dopamine levels in the brain. But did you know that PD also alters serotonin, norepinephrine and acetylcholine levels? All are chemicals in the brain that affect mood, thinking and behavior. Not everyone with Parkinson’s will experience cognitive change. And for the 30 percent of…
- Research Roundup: Cognition Changes and Parkinson’s 101 July 26, 2017 If you have Parkinson’s disease (PD), or know someone who does, you likely know that PD affects dopamine levels in the brain. But did you know that PD also alters serotonin, norepinephrine and acetylcholine levels? All are chemicals in the brain that affect mood, thinking and behavior. Not everyone with Parkinson’s will experience cognitive change. And for the 30 percent of…
- The Tau of LRRK2 December 3, 2019 Dense spherical clusters of a protein – called Lewy bodies – are one of the classical hallmarks of the Parkinsonian brain. They are a common pathological feature, but curiously they are not present in all cases of Parkinson’s. For example, some individuals with certain forms of Parkinson’s associated with specific genetic mutations do not exhibit any Lewy bodies. Variations…
- Hippocampal CA1 subfield predicts episodic memory impairment in Parkinson's disease. May 6, 2019 Related ArticlesHippocampal CA1 subfield predicts episodic memory impairment in Parkinson's disease. Neuroimage Clin. 2019 Apr 18;23:101824 Authors: La C, Linortner P, Bernstein JD, Ua Cruadhlaoich MAI, Fenesy M, Deutsch GK, Rutt BK, Tian L, Wagner AD, Zeineh M, Kerchner GA, Poston KL Abstract OBJECTIVE: Parkinson's disease (PD) episodic memory impairments are common; however, it is not known whether these impairments…
- Diet and Dementia (Cognitive Decline) in the Aging August 14, 2017 “When diet is wrong medicine is of no use. When diet is correct medicine is of no need.’’ Ancient Ayurvedic Proverb ‘‘What is food to one man may be fierce poison to others.’’ Lucretius (99 B.C.-55 BC). Précis: Last month in London, England, at the Alzheimer’s Association International Conference (AAIC) 2017, there were several presentations focused on diet and the…
- Gout Not Causally Associated With Alzheimer Disease May 10, 2019 A Mendelian randomization analysis relying on genome-wide association studies (GWASs) found no causal association between gout and Alzheimer disease, according to a report published in the International Journal of Rheumatic Diseases. Given its known antioxidant effects, uric acid has been proposed as potentially neuroprotective, particularly against AD, in which oxidative stress has been implicated. Despite research suggesting an inverse causal…
- The Difference Between Lewy Body Dementia, Parkinson’s Disease and Alzheimer’s Disease March 8, 2018 Lewy Body Dementia: A Common Yet Underdiagnosed Dementia While it’s not a household word yet, Lewy body dementia (LBD) is not a rare disease. It affects an estimated 1.4 million individuals and their families in the United States. Because LBD symptoms can closely resemble other more commonly known disorders like Alzheimer’s disease and Parkinson’s, it is often underdiagnosed or misdiagnosed.…
- Monthly Research Review – November 2019 November 30, 2019 At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during November 2019. The post is divided into seven parts based on the type of research: Basic biology Disease mechanism Clinical research New clinical trials Clinical trial news Other news Review…
- Working Memory in Alzheimer's Disease and Parkinson's Disease. July 28, 2019 Related ArticlesWorking Memory in Alzheimer's Disease and Parkinson's Disease. Curr Top Behav Neurosci. 2019 Jul 26;: Authors: Zokaei N, Husain M Abstract Working memory impairments are frequently observed in patients with Alzheimer's disease (AD) and Parkinson's disease (PD). Recent research suggests that the mechanisms underlying these deficits might be dissociable using sensitive tasks, specifically those that rely on the reproduction…
- Let’s talk about brain donation September 17, 2019 Let’s talk about brain donation One of the most fundamental ways for scientists to learn about Parkinson’s disease (PD) as well as other brain disorders, is by studying the brain tissue of people with these diseases. There is never too much of this extremely valuable material for research studies. While there are major strides in developing cellular and animal models…
- Curasen: Shifting the focus from just dopamine December 8, 2020 # # # # In September, a small biotech company called CuraSen announced that they had dosed the first participant in a clinical trial of their new experimental drug for Parkinson’s. This news did not garner a lot of attention, but was of great interest to us here at the SoPD because the drug – currently named CST-2032 – is…
- Preserved caudate function in young-onset patients with Parkinson's disease: a dual-tracer PET imaging study. June 18, 2019 Preserved caudate function in young-onset patients with Parkinson's disease: a dual-tracer PET imaging study. Ther Adv Neurol Disord. 2019;12:1756286419851400 Authors: Yang YJ, Ge JJ, Liu FT, Liu ZY, Zhao J, Wu JJ, Ma Y, Zuo CT, Wang J Abstract Parkinson's disease (PD) is a highly heterogeneous clinical entity. Patients with young-onset PD (YOPD) show some characteristic manifestations to late-onset PD…