Misfolded α-Synuclein Assessment in Skin and CSF by RT-QuIC in Isolated REM Sleep Behavior Disorder

Misfolded α-Synuclein Assessment in Skin and CSF by RT-QuIC in Isolated REM Sleep Behavior Disorder
Neurology. 2023 Mar 17:10.1212/WNL.0000000000207147. doi: 10.1212/WNL.0000000000207147. Online ahead of print.ABSTRACTBACKGROUND AND OBJECTIVES: Real-time quaking-induced conversion (RT-QuIC) assay detects misfolded α-synuclein in the skin and CSF of patients with the synucleinopathies Parkinson disease and dementia with Lewy bodies. Isolated REM sleep behavior disorder (IRBD) constitutes the prodromal stage of these synucleinopathies. We aimed to compare the ability of RT-QuIC to identify ... read more
Source: PubMedPublished on 2023-03-17By Alex Iranzo