Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis

Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis
Cell. 2022 Jul 29:S0092-8674(22)00790-5. doi: 10.1016/j.cell.2022.06.038. Online ahead of print.ABSTRACTAlthough mutations in mitochondrial-associated genes are linked to inflammation and susceptibility to infection, their mechanistic contributions to immune outcomes remain ill-defined. We discovered that the disease-associated gain-of-function allele Lrrk2G2019S (leucine-rich repeat kinase 2) perturbs mitochondrial homeostasis and reprograms cell death pathways in macrophages. When the inflammasome is activated in Lrrk2G2019S macrophages, ... read more
Source: PubMedPublished on 2022-07-30By Chi G Weindel