Molecular simulations reveal terminal group mediated stabilization of helical conformers in both amyloid-β42 and α-synuclein.

Molecular simulations reveal terminal group mediated stabilization of helical conformers in both amyloid-β42 and α-synuclein.
Molecular simulations reveal terminal group mediated stabilization of helical conformers in both amyloid-β42 and α-synuclein. ACS Chem Neurosci. 2019 Mar 27;: Authors: Bhattacharya S, Xu L, Thompson D Abstract The presence of partially structured helices in natively unfolded amyloid-β42 (Aβ42) and α-synuclein (αS) has been shown to accelerate fibrillation in the onset of Alzheimer's and Parkinson's disease, respectively. At the ... read more
Source: PubMedPublished on 2019-03-29