mTOR hyperactivity mediates lysosomal dysfunction in Gaucher’s disease iPSC-neuronal cells.

mTOR hyperactivity mediates lysosomal dysfunction in Gaucher’s disease iPSC-neuronal cells.
Related ArticlesmTOR hyperactivity mediates lysosomal dysfunction in Gaucher's disease iPSC-neuronal cells. Dis Model Mech. 2019 Sep 13;: Authors: Brown RA, Voit A, Srikanth MP, Thayer JA, Kingsbury TJ, Jacobson MA, Lipinski MM, Feldman RA, Awad O Abstract Bi-allelic GBA1 mutations cause Gaucher's disease (GD), the most common lysosomal storage disorder (LSD). Neuronopathic manifestations in GD include neurodegeneration, which can be ... read more
Source: PubMedPublished on 2019-09-15