Multiple Beneficial Effects of Ghrelin Agonist, HM01 on Homeostasis Alterations in 6-Hydroxydopamine Model of Parkinson’s Disease in Male Rats.

Related Articles:

• Resveratrol delays 6-hydroxydopamine-induced apoptosis by activating the PI3K/Akt signaling pathway. July 12, 2019 Resveratrol delays 6-hydroxydopamine-induced apoptosis by activating the PI3K/Akt signaling pathway. Exp Gerontol. 2019 Jul 08;:110653 Authors: Huang N, Zhang Y, Chen M, Jin H, Nie J, Luo Y, Zhou S, Shi J, Jin F Abstract This study aimed to determine whether resveratrol (Res) delays the progression of 6-hydroxydopamine (6-OHDA)-induced apoptosis via activating the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling…
• Positive effect of an electrolyzed reduced water on gut permeability, fecal microbiota and liver in an animal model of Parkinson's disease. October 11, 2019 Positive effect of an electrolyzed reduced water on gut permeability, fecal microbiota and liver in an animal model of Parkinson's disease. PLoS One. 2019;14(10):e0223238 Authors: Bordoni L, Gabbianelli R, Fedeli D, Fiorini D, Bergheim I, Jin CJ, Marinelli L, Di Stefano A, Nasuti C Abstract There is growing awareness within the scientific community of the strong connection between the inflammation…
• Guanosine prevents depressive-like behaviors in rats following bilateral dorsolateral striatum lesion induced by 6-hydroxydopamine. June 19, 2019 Guanosine prevents depressive-like behaviors in rats following bilateral dorsolateral striatum lesion induced by 6-hydroxydopamine. Behav Brain Res. 2019 Jun 15;:112014 Authors: Marques NF, Binder LB, Roversi K, Sampaio TB, Constantino LC, Prediger RD, Tasca CI Abstract The dorsolateral striatum (DLS) processes motor and non-motor functions and undergoes extensive dopaminergic degeneration in Parkinson's disease (PD). Beyond the nigrostriatal pathway, dopaminergic degeneration…
• Effects of bromelain on motor responses following intra-medial forebrain bundle 6-OHDA injection in rat model of parkinsonism. July 24, 2019 Related ArticlesEffects of bromelain on motor responses following intra-medial forebrain bundle 6-OHDA injection in rat model of parkinsonism. Metab Brain Dis. 2019 Jul 22;: Authors: Adu TS, Mabandla MV Abstract Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta. The conventional therapeutic measures which include the widely used L-DOPA therapy, are…
• Effects of carvacrol and physical exercise on motor and memory impairments associated with Parkinson's disease. August 1, 2019 Effects of carvacrol and physical exercise on motor and memory impairments associated with Parkinson's disease. Arq Neuropsiquiatr. 2019 Jul 29;77(7):493-500 Authors: Hamzehloei L, Rezvani ME, Rajaei Z Abstract The present study was undertaken to investigate the effects of carvacrol and treadmill exercise on memory deficit, rotational behavior and oxidative stress biomarkers in a 6-OHDA-lesioned rat model of Parkinson's disease. Wistar…
• Effect of cerebral dopamine neurotrophic factor on endogenous neural progenitor cell migration in a rat model of Parkinson's disease. April 9, 2019 Related ArticlesEffect of cerebral dopamine neurotrophic factor on endogenous neural progenitor cell migration in a rat model of Parkinson's disease. EXCLI J. 2019;18:139-153 Authors: Nasrolahi A, Mahmoudi J, Karimipour M, Akbarzadeh A, Sadigh-Eteghad S, Salehi R, Farajdokht F, Farhoudi M Abstract This study investigated the ability of intra-subventricular zone (SVZ) administration of cerebral dopamine neurotrophic factor (CDNF) on neural progenitor…
• [The efficacy of tes-therapy for treatment of anxiety-like behavior and motor disorders in rats with an experimental model of parkinsonism]. October 19, 2019 [The efficacy of tes-therapy for treatment of anxiety-like behavior and motor disorders in rats with an experimental model of parkinsonism]. Zh Nevrol Psikhiatr Im S S Korsakova. 2019;119(9):91-96 Authors: Kade AK, Kravchenko SV, Trofimenko AI, Chaplygina KY, Ananeva EI, Poliakov PP, Lipatova AS Abstract AIM: To assess the efficacy of transcranial electrostimulation TES for treatmnet of anxiety-like behavior and motor…
• Effects of Boswellia serrata resin extract on motor dysfunction and brain oxidative stress in an experimental model of Parkinson's disease. May 31, 2019 Related ArticlesEffects of Boswellia serrata resin extract on motor dysfunction and brain oxidative stress in an experimental model of Parkinson's disease. Avicenna J Phytomed. 2019 May-Jun;9(3):281-290 Authors: Doaee P, Rajaei Z, Roghani M, Alaei H, Kamalinejad M Abstract Objective: Boswellia serrata oleo-gum resin (frankincense) exerted antioxidant and anti-inflammatory effects against several diseases, such as; asthma, rheumatoid arthritis and irritable bowel…
• Differential Effects of LPS and 6-OHDA on Microglia's Morphology in Rats: Implications for Inflammatory Model of Parkinson's Disease. September 4, 2019 Related ArticlesDifferential Effects of LPS and 6-OHDA on Microglia's Morphology in Rats: Implications for Inflammatory Model of Parkinson's Disease. Neurotox Res. 2019 Sep 02;: Authors: Parra I, Martínez I, Ramírez-García G, Tizabi Y, Mendieta L Abstract Parkinson's disease (PD) is an idiopathic and progressive neurodegenerative disease characterized by the loss of ~ 80% of dopaminergic neurons in substantia nigra pars compacta…
• Dopamine Receptor D1 Agonism Induces Dynamin Related Protein-1 Inhibition to Improve Mitochondrial Biogenesis and Dopaminergic Neurogenesis in Rat Model of Parkinson's disease. October 19, 2019 Dopamine Receptor D1 Agonism Induces Dynamin Related Protein-1 Inhibition to Improve Mitochondrial Biogenesis and Dopaminergic Neurogenesis in Rat Model of Parkinson's disease. Behav Brain Res. 2019 Oct 15;:112304 Authors: Mishra A, Singh S, Tiwari V, Bano S, Shukla S Abstract Dopamine (DA) neurotransmitter act on dopamine receptors (D1-D5) to regulate motor functions, reward, addiction and cognitive behavior. The depletion of…
• c-Fos Expression after Stochastic Vestibular Stimulation and Levodopa in 6-OHDA Hemilesioned Rats. November 11, 2019 Related Articlesc-Fos Expression after Stochastic Vestibular Stimulation and Levodopa in 6-OHDA Hemilesioned Rats. Neuroscience. 2019 Nov 05;: Authors: Samoudi G, Nilsson A, Carlsson T, Bergquist F Abstract Near threshold stochastic vestibular stimulation (SVS) enhances postural control and improves other symptoms in neurodegenerative disorders like Parkinson's disease (PD). Improvement of postural control can tentatively be explained by increased responsivity of the…
• Circulating messenger for neuroprotection induced by molecular hydrogen. May 18, 2019 Circulating messenger for neuroprotection induced by molecular hydrogen. Can J Physiol Pharmacol. 2019 May 17;: Authors: Noda M, Uemura Y, Yoshii Y, Horita T, Takemi S, Sakata I, Sakai T Abstract Molecular hydrogen (H2) showed protection against various kinds of oxidative stress-related diseases. First it was reported that the mechanism of therapeutic effects of H2 was anti-oxidative effect due to…
• Dopamine receptor activation mitigates mitochondrial dysfunction and oxidative stress to enhance dopaminergic neurogenesis in 6-OHDA lesioned rats: A role of Wnt signalling. May 13, 2019 Dopamine receptor activation mitigates mitochondrial dysfunction and oxidative stress to enhance dopaminergic neurogenesis in 6-OHDA lesioned rats: A role of Wnt signalling. Neurochem Int. 2019 May 09;:104463 Authors: Mishra A, Singh S, Tiwari V, Chaturvedi S, Wahajuddin M, Shukla S Abstract Nigral dopaminergic (DAergic) cell degeneration and depletion of dopamine neurotransmitter in the midbrain are cardinal features of Parkinson's disease…
• Neuroprotective effects of lignan 7-hydroxymatairesinol (HMR/lignan) in a rodent model of Parkinson's disease. October 6, 2019 Neuroprotective effects of lignan 7-hydroxymatairesinol (HMR/lignan) in a rodent model of Parkinson's disease. Nutrition. 2019 Apr 25;69:110494 Authors: Giuliano C, Siani F, Mus L, Ghezzi C, Cerri S, Pacchetti B, Bigogno C, Blandini F Abstract OBJECTIVES: Parkinson's disease (PD) is a neurodegenerative disease characterized by loss of dopaminergic neurons in the Substantia Nigra pars compacta (SNc). The proinflammatory response can…
• Thirteen-Week Oral Toxicity Evaluation of Erinacine AEnriched Lion's Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), Mycelia in Sprague-Dawley Rats. April 20, 2019 Related ArticlesThirteen-Week Oral Toxicity Evaluation of Erinacine AEnriched Lion's Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), Mycelia in Sprague-Dawley Rats. Int J Med Mushrooms. 2019;21(4):401-411 Authors: Lee LY, Li IC, Chen WP, Tsai YT, Chen CC, Tung KC Abstract Recently, erinacine A-enriched Hericium erinaceus (EAHE) mycelia have demonstrated therapeutic efficacy in animal models of neurodegenerative disease, including Alzheimer and Parkinson disease.…
• Activation and blockade of dorsal hippocampal Serotonin6 receptors regulate anxiety-like behaviors in a unilateral 6-hydroxydopamine rat model of Parkinson's disease. May 6, 2019 Activation and blockade of dorsal hippocampal Serotonin6 receptors regulate anxiety-like behaviors in a unilateral 6-hydroxydopamine rat model of Parkinson's disease. Neurol Res. 2019 May 06;:1-11 Authors: Liu KC, Guo Y, Zhang J, Chen L, Liu YW, Lv SX, Xie W, Wang HS, Zhang YM, Zhang L Abstract OBJECTIVES: This study aimed to investigate the effect of serotonin6 (5-HT6) receptors in…
• Trabecular meshwork mesenchymal stem cell transplantation improve motor symptoms of parkinsonian rat model. July 3, 2019 Related ArticlesTrabecular meshwork mesenchymal stem cell transplantation improve motor symptoms of parkinsonian rat model. Biologicals. 2019 Jun 29;: Authors: Mostafavi H, Ghassemifard L, Rostami A, Alipour M, Nadri S Abstract Stem cell transplantation is a new therapeutic strategy in the treatment of neurodegenerative disorders such as Parkinson's disease (PD). Therefore, in this study, the therapeutic effects of Trabecular Meshwork Mesenchymal…
• Activation and blockade of serotonin4 receptors in the lateral habenula improve working memory in unilateral 6-hydroxydopamine-lesioned Parkinson's rats. April 2, 2019 Related ArticlesActivation and blockade of serotonin4 receptors in the lateral habenula improve working memory in unilateral 6-hydroxydopamine-lesioned Parkinson's rats. Neurol Res. 2019 Mar 30;:1-9 Authors: Guo Y, Zhang L, Zhang J, Du CX, Lv SX, Wang T, Wang HS, Xie W, Liu J Abstract OBJECTIVE: The aim of the present study was to investigate the effects and mechanism of 6-hydroxydopamine…
• Serotonin1A receptors in the dorsal hippocampus regulate working memory and long-term habituation in the hemiparkinsonian rats. September 3, 2019 Related ArticlesSerotonin1A receptors in the dorsal hippocampus regulate working memory and long-term habituation in the hemiparkinsonian rats. Behav Brain Res. 2019 Aug 30;:112207 Authors: Liu Y, Liu J, Jiao SR, Liu X, Guo Y, Zhang J, Yang J, Xie W, Wang HS, Zhang L Abstract Although the dorsal hippocampus (dHPC) and serotonin1A (5-HT1A) receptor are involved in cognition, their roles…
• Oleanolic Acid Mitigates 6-Hydroxydopamine Neurotoxicity by Attenuating Intracellular ROS in PC12 Cells and Striatal Microglial Activation in Rat Brains. September 10, 2019 Oleanolic Acid Mitigates 6-Hydroxydopamine Neurotoxicity by Attenuating Intracellular ROS in PC12 Cells and Striatal Microglial Activation in Rat Brains. Front Physiol. 2019;10:1059 Authors: Msibi ZNP, Mabandla MV Abstract Oleanolic acid (OA), a biologically active pentacyclic triterpenoid compound, has been implicated in a number of clinical benefits including antioxidant, and anti-inflammatory properties. OA has been previously shown to ameliorate the toxic…