Multitargeting nature of muscarinic orthosteric agonists and antagonists

Multitargeting nature of muscarinic orthosteric agonists and antagonists
Front Physiol. 2022 Sep 6;13:974160. doi: 10.3389/fphys.2022.974160. eCollection 2022.ABSTRACTMuscarinic receptors (mAChRs) are typical members of the G protein-coupled receptor (GPCR) family and exist in five subtypes from M1 to M5. Muscarinic receptor subtypes do not sufficiently differ in affinity to orthosteric antagonists or agonists; therefore, the analysis of receptor subtypes is complicated, and misinterpretations can occur. Usually, when researchers mainly ... read more
Source: PubMedPublished on 2022-09-23By Jaromir Myslivecek