Neuroprotective effects of a lead compound from coral via modulation of the orphan nuclear receptor Nurr1

Neuroprotective effects of a lead compound from coral via modulation of the orphan nuclear receptor Nurr1
CNS Neurosci Ther. 2022 Nov 23. doi: 10.1111/cns.14025. Online ahead of print.ABSTRACTAIMS: To screen coral-derived compounds with neuroprotective activity and clarify the potential mechanism of lead compounds.METHODS: The lead compounds with neuroprotective effects were screened by H2 O2 and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPP+ )-induced cell damage models in SH-SY5Y cells. CCK8 and LDH assays were used to detect cell viability. The anti-apoptosis ... read more
Source: PubMedPublished on 2022-11-24By Jian-Wei Su