Novel therapeutic approaches for Parkinson’s disease by targeting brain cholesterol homeostasis

Novel therapeutic approaches for Parkinson’s disease by targeting brain cholesterol homeostasis
J Pharm Pharmacol. 2021 Apr 3:rgaa063. doi: 10.1093/jpp/rgaa063. Online ahead of print.ABSTRACTOBJECTIVES: Human brain is composed of 25% of the cholesterol & any dysfunction in brain cholesterol homeostasis contributes to neurodegenerative disorders such as Parkinson, Alzheimer's, Huntington's disease, etc. A growing literature indicates that alteration in neurotransmission & brain cholesterol metabolism takes place in the early stage of the disease. ... read more
Source: PubMedPublished on 2021-04-06By Tanvi Dayanand Pingale