Clin Neuropharmacol. 2023 Jan 23. doi: 10.1097/WNF.0000000000000538. Online ahead of print.ABSTRACTOBJECTIVES: Levodopa (LD) administered with dopa decarboxylase inhibitor is predominantly metabolized in the periphery by catechol-O-methyltransferase (COMT) to 3-O-methyldopa (3-OMD). Catechol-O-methyltransferase inhibition can improve treatment outcomes by decreasing variability in circulating LD concentrations. Opicapone is a once-daily COMT inhibitor approved in the US adjunctive to carbidopa (CD)/LD in patients with ... read more
Source: PubMedPublished on 2023-01-23By Peter LeWitt
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