Oxidative Stress Conditions Result in Trapping of PHF-Core Tau (297-391) Intermediates

Oxidative Stress Conditions Result in Trapping of PHF-Core Tau (297-391) Intermediates
Cells. 2021 Mar 22;10(3):703. doi: 10.3390/cells10030703.ABSTRACTThe self-assembly of tau into paired helical filaments (PHFs) in neurofibrillary tangles (NFTs) is a significant event in Alzheimer's disease (AD) pathogenesis. Numerous post-translational modifications enhance or inhibit tau assembly into NFTs. Oxidative stress, which accompanies AD, induces multiple post-translational modifications in proteins, including the formation of dityrosine (DiY) cross-links. Previous studies have revealed that ... read more
Source: PubMedPublished on 2021-04-03By Mahmoud B Maina