Parkin coregulates glutathione metabolism in adult mammalian brain

Parkin coregulates glutathione metabolism in adult mammalian brain
Acta Neuropathol Commun. 2023 Jan 23;11(1):19. doi: 10.1186/s40478-022-01488-4.ABSTRACTWe recently discovered that the expression of PRKN, a young-onset Parkinson disease-linked gene, confers redox homeostasis. To further examine the protective effects of parkin in an oxidative stress model, we first combined the loss of prkn with Sod2 haploinsufficiency in mice. Although adult prkn-/-//Sod2± animals did not develop dopamine cell loss in the ... read more
Source: PubMedPublished on 2023-01-23By Daniel N El Kodsi