Parkinson’s Clustering in Families of Non-Neuronopathic N370S GBA Mutation Carriers Indicates the Presence of Genetic Modifiers

Parkinson’s Clustering in Families of Non-Neuronopathic N370S GBA Mutation Carriers Indicates the Presence of Genetic Modifiers
J Parkinsons Dis. 2021 Feb 19. doi: 10.3233/JPD-202422. Online ahead of print.ABSTRACTLow penetrance of Parkinson's disease (PD) associated with GBA pathogenic variants indicates the presence of modifiers genes. Clusters of PD cases in certain families with GBA variants would serve as a strong evidence for the clinical relevance of such modifiers. We studied eight family trees of non-Parkinsonian, GBA-N370S homozygote, ... read more
Source: PubMedPublished on 2021-02-22By Tama Dinur