Parkinson’s Disease: Dual Action of Key Protein Detected – MedicalResearch.com

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• The road ahead: 2022 January 20, 2022 # # # # The first post at the start of each year on the SoPD website tries to provide an overview of where things are in the search for ‘disease modifying’ therapies for Parkinson’s.  It is an exercise in managing expectations as well as discussing what research events are scheduled for the next year so that we can keep…
• Action Observation and Motor Imagery Improve Dual Task in Parkinson's Disease: A Clinical/fMRI Study July 21, 2021 Mov Disord. 2021 Jul 19. doi: 10.1002/mds.28717. Online ahead of print.ABSTRACTBACKGROUND: Action observation training and motor imagery may improve motor learning in Parkinson's disease (PD).OBJECTIVES: The objectives of this study were to assess mobility and balance (performing motor and dual tasks) and brain functional reorganization following 6 weeks of action observation training and motor imagery associated with dual-task gait/balance exercises…
• Action Observation and Motor Imagery Improve Dual Task in Parkinson's Disease: A Clinical/fMRI Study July 21, 2021 Mov Disord. 2021 Jul 19. doi: 10.1002/mds.28717. Online ahead of print.ABSTRACTBACKGROUND: Action observation training and motor imagery may improve motor learning in Parkinson's disease (PD).OBJECTIVES: The objectives of this study were to assess mobility and balance (performing motor and dual tasks) and brain functional reorganization following 6 weeks of action observation training and motor imagery associated with dual-task gait/balance exercises…
• Action Observation and Motor Imagery Improve Dual Task in Parkinson's Disease: A Clinical/fMRI Study July 21, 2021 Mov Disord. 2021 Jul 19. doi: 10.1002/mds.28717. Online ahead of print.ABSTRACTBACKGROUND: Action observation training and motor imagery may improve motor learning in Parkinson's disease (PD).OBJECTIVES: The objectives of this study were to assess mobility and balance (performing motor and dual tasks) and brain functional reorganization following 6 weeks of action observation training and motor imagery associated with dual-task gait/balance exercises…
• Action Observation and Motor Imagery Improve Dual Task in Parkinson's Disease: A Clinical/fMRI Study July 21, 2021 Mov Disord. 2021 Jul 19. doi: 10.1002/mds.28717. Online ahead of print.ABSTRACTBACKGROUND: Action observation training and motor imagery may improve motor learning in Parkinson's disease (PD).OBJECTIVES: The objectives of this study were to assess mobility and balance (performing motor and dual tasks) and brain functional reorganization following 6 weeks of action observation training and motor imagery associated with dual-task gait/balance exercises…
• Action Observation and Motor Imagery Improve Dual Task in Parkinson's Disease: A Clinical/fMRI Study July 21, 2021 Mov Disord. 2021 Jul 19. doi: 10.1002/mds.28717. Online ahead of print.ABSTRACTBACKGROUND: Action observation training and motor imagery may improve motor learning in Parkinson's disease (PD).OBJECTIVES: The objectives of this study were to assess mobility and balance (performing motor and dual tasks) and brain functional reorganization following 6 weeks of action observation training and motor imagery associated with dual-task gait/balance exercises…
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• The road ahead: 2021 January 25, 2021 # # # # At the start of each year, it is a useful practise to layout what is planned over the next 12 months. The events that are scheduled for the year to come, so that we can keep an eye out for them. Obviously, where 2021 will end actually is unpredictable, but an outline of what is scheduled…
• Cognitive and motor dual task gait training exerted specific training effects on dual task gait performance in individuals with Parkinson's disease: A randomized controlled pilot study. June 21, 2019 Cognitive and motor dual task gait training exerted specific training effects on dual task gait performance in individuals with Parkinson's disease: A randomized controlled pilot study. PLoS One. 2019;14(6):e0218180 Authors: Yang YR, Cheng SJ, Lee YJ, Liu YC, Wang RY Abstract Gait impairments in Parkinson's disease (PD) are aggravated under dual task conditions. Providing effective training to enhance different dual…
• Dual-task clinical and functional MRI correlates in Parkinson's disease with postural instability and gait disorders September 21, 2021 Parkinsonism Relat Disord. 2021 Sep 15;91:88-95. doi: 10.1016/j.parkreldis.2021.09.003. Online ahead of print.ABSTRACTBACKGROUND: Dual-task is a challenge for Parkinson's disease patients with postural instability and gait disorders (PD-PIGD).OBJECTIVE: This study investigated clinical, cognitive and functional brain correlates of dual-task deficits in PD-PIGD patients using quantitative gait analysis, neuropsychological evaluations and functional MRI (fMRI).METHODS: Twenty-three PD-PIGD patients performed a clinical assessment of…
• Dual-task clinical and functional MRI correlates in Parkinson's disease with postural instability and gait disorders September 21, 2021 Parkinsonism Relat Disord. 2021 Sep 15;91:88-95. doi: 10.1016/j.parkreldis.2021.09.003. Online ahead of print.ABSTRACTBACKGROUND: Dual-task is a challenge for Parkinson's disease patients with postural instability and gait disorders (PD-PIGD).OBJECTIVE: This study investigated clinical, cognitive and functional brain correlates of dual-task deficits in PD-PIGD patients using quantitative gait analysis, neuropsychological evaluations and functional MRI (fMRI).METHODS: Twenty-three PD-PIGD patients performed a clinical assessment of…
• Dual-task clinical and functional MRI correlates in Parkinson's disease with postural instability and gait disorders September 21, 2021 Parkinsonism Relat Disord. 2021 Sep 15;91:88-95. doi: 10.1016/j.parkreldis.2021.09.003. Online ahead of print.ABSTRACTBACKGROUND: Dual-task is a challenge for Parkinson's disease patients with postural instability and gait disorders (PD-PIGD).OBJECTIVE: This study investigated clinical, cognitive and functional brain correlates of dual-task deficits in PD-PIGD patients using quantitative gait analysis, neuropsychological evaluations and functional MRI (fMRI).METHODS: Twenty-three PD-PIGD patients performed a clinical assessment of…
• Dual-task clinical and functional MRI correlates in Parkinson's disease with postural instability and gait disorders September 21, 2021 Parkinsonism Relat Disord. 2021 Sep 15;91:88-95. doi: 10.1016/j.parkreldis.2021.09.003. Online ahead of print.ABSTRACTBACKGROUND: Dual-task is a challenge for Parkinson's disease patients with postural instability and gait disorders (PD-PIGD).OBJECTIVE: This study investigated clinical, cognitive and functional brain correlates of dual-task deficits in PD-PIGD patients using quantitative gait analysis, neuropsychological evaluations and functional MRI (fMRI).METHODS: Twenty-three PD-PIGD patients performed a clinical assessment of…
• Dual-task clinical and functional MRI correlates in Parkinson's disease with postural instability and gait disorders September 21, 2021 Parkinsonism Relat Disord. 2021 Sep 15;91:88-95. doi: 10.1016/j.parkreldis.2021.09.003. Online ahead of print.ABSTRACTBACKGROUND: Dual-task is a challenge for Parkinson's disease patients with postural instability and gait disorders (PD-PIGD).OBJECTIVE: This study investigated clinical, cognitive and functional brain correlates of dual-task deficits in PD-PIGD patients using quantitative gait analysis, neuropsychological evaluations and functional MRI (fMRI).METHODS: Twenty-three PD-PIGD patients performed a clinical assessment of…
• Speech, Voice & Parkinson’s Q&A with John Dean January 28, 2021 We recently hosted a webinar with speech-language pathologist John Dean. You can get access to the recording here. We received so many questions during the session that we weren’t able to answer them all; so, John was kind enough to do some written Q&A for us. “When is a good time to start speech therapy?” It’s much better to maintain…
• Dual-Task Costs of Quantitative Gait Parameters While Walking and Turning in People with Parkinson's Disease: Beyond Gait Speed. January 4, 2021 Related ArticlesDual-Task Costs of Quantitative Gait Parameters While Walking and Turning in People with Parkinson's Disease: Beyond Gait Speed. J Parkinsons Dis. 2020 Dec 29;: Authors: Vitorio R, Hasegawa N, Carlson-Kuhta P, Nutt JG, Horak FB, Mancini M, Shah VV Abstract BACKGROUND: There is a lack of recommendations for selecting the most appropriate gait measures of Parkinson's disease (PD)-specific dual-task…
• Dual vs. Single Tasking During Circular Walking: What Better Reflects Progression in Parkinson's Disease? May 30, 2019 Dual vs. Single Tasking During Circular Walking: What Better Reflects Progression in Parkinson's Disease? Front Neurol. 2019;10:372 Authors: Micó-Amigo ME, Kingma I, Heinzel S, Nussbaum S, Heger T, van Lummel RC, Berg D, Maetzler W, van Dieën JH Abstract Background and Aim: Reliable, valid and sensitive measures of dual-task-associated impairments in patients with Parkinson's disease (PD) may reveal progressive deficits…
• The road ahead: 2020 January 5, 2020 Here at the SoPD, we are primarily interested in disease modification for Parkinson’s. While there is a great deal of interesting research exploring the causes of the condition, novel symptomatic therapies, and other aspects of Parkinson’s, my focus is generally on the science seeking to slow, stop or reverse the condition. At the start of each year, it is a…
• Parkinson’s Disease, Freezing of Gait and Walking Automaticity May 9, 2022 Many walking abnormalities in people with Parkinson’s disease may be characterized by a shift in locomotor control from healthy automaticity by basal ganglia to compensatory executive control by the cerebral cortex (1). This shift to less automaticity is potentially detrimental to walking performance as executive control strategies are not optimized for locomotor control, place excessive demands on a limited cognitive…
• Monthly Research Review – November 2019 November 30, 2019   At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during November 2019. The post is divided into seven parts based on the type of research: Basic biology Disease mechanism Clinical research New clinical trials Clinical trial news Other news Review…
• Simple Smartphone-Based Assessment of Gait Characteristics in Parkinson Disease: Validation Study. February 20, 2021 Related ArticlesSimple Smartphone-Based Assessment of Gait Characteristics in Parkinson Disease: Validation Study. JMIR Mhealth Uhealth. 2021 Feb 19;9(2):e25451 Authors: Su D, Liu Z, Jiang X, Zhang F, Yu W, Ma H, Wang C, Wang Z, Wang X, Hu W, Manor B, Feng T, Zhou J Abstract BACKGROUND: Parkinson disease (PD) is a common movement disorder. Patients with PD have multiple…