Parkinson’s Disease: Focus on Hallucinations – Medscape

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• Ask the expert: How can hallucinations affect people with Parkinson’s? January 14, 2021 Around 50% of people with Parkinson’s disease will experience hallucinations. But what are they – and what causes them? In the latest in our ‘Ask the expert’ series, Professor Per Odin shares what you need to know about the symptom What are hallucinations? Hallucinations are sensory experiences that appear real but are created by our brains. They can affect all…
• Visual Hallucinations Linked to Retinal Thinning in Parkinson’s, Study Reports December 14, 2020 Visual hallucinations in people with Parkinson’s disease are associated with a thinning of the inner layers of the eye’s retina, an exploratory study reported.  Published in the journal Nature Scientific Reports, the study was titled “Visual hallucinations in Parkinson’s disease are associated with thinning of the inner retina.” Such hallucinations are common in people with Parkinson’s, yet the underlying mechanisms…
• Hallucinations Can Be a Scary Side Effect of Parkinson’s March 3, 2022 Do you see or hear things that others don’t? According to the Parkinson’s Foundation, 20–40% of Parkinson’s patients say they’ve experienced hallucinations or delusions. The foundation’s website states, “Hallucinations are when someone sees, hears or feels something that is not actually there.” Unlike dreams, these episodes occur when the person is awake and can happen at any time during the…
• Sleep-related hallucinations in patients with Parkinson's disease October 25, 2022 PLoS One. 2022 Oct 25;17(10):e0276736. doi: 10.1371/journal.pone.0276736. eCollection 2022.ABSTRACTGiven that sleep-wake cycle dysfunction can cause hallucinations in Parkinson's disease patients, sleep-related hallucinations may be a different subtype from hallucinations that occur only during full wakefulness. However, few studies that distinguish the onset situations of hallucinations related to sleep from those that occur in full wakefulness have been conducted to investigate…
• Sleep-related hallucinations in patients with Parkinson's disease October 25, 2022 PLoS One. 2022 Oct 25;17(10):e0276736. doi: 10.1371/journal.pone.0276736. eCollection 2022.ABSTRACTGiven that sleep-wake cycle dysfunction can cause hallucinations in Parkinson's disease patients, sleep-related hallucinations may be a different subtype from hallucinations that occur only during full wakefulness. However, few studies that distinguish the onset situations of hallucinations related to sleep from those that occur in full wakefulness have been conducted to investigate…
• Sleep-related hallucinations in patients with Parkinson's disease October 25, 2022 PLoS One. 2022 Oct 25;17(10):e0276736. doi: 10.1371/journal.pone.0276736. eCollection 2022.ABSTRACTGiven that sleep-wake cycle dysfunction can cause hallucinations in Parkinson's disease patients, sleep-related hallucinations may be a different subtype from hallucinations that occur only during full wakefulness. However, few studies that distinguish the onset situations of hallucinations related to sleep from those that occur in full wakefulness have been conducted to investigate…
• [Video] Parkinson’s Disease Psychosis with Dr. Christopher Goetz September 9, 2020 Parkinson’s disease psychosis is a non-motor symptom of Parkinson’s that causes people to experience hallucinations and/or delusions. Approximately 50% of all people living with Parkinson’s will experience some form of hallucinations or delusions, and the longer one lives with Parkinson’s, the greater the likelihood they’ll experience them.  Here are some of the questions that were answered during the webinar: What…
• Medicare Claims Data Underestimate Hallucinations in Older Adults With Dementia August 28, 2021 Am J Geriatr Psychiatry. 2021 Aug 5:S1064-7481(21)00413-9. doi: 10.1016/j.jagp.2021.07.018. Online ahead of print.ABSTRACTOBJECTIVE: Administrative claims data are used to study the incidence and outcomes of dementia-related hallucinations, but the validity of International Classification of Diseases (ICD) codes for identifying dementia-related hallucinations is unknown.METHODS: We analyzed Medicare-linked survey data from 2 nationally representative studies of U.S. older adults (the National Health…
• Medicare Claims Data Underestimate Hallucinations in Older Adults With Dementia August 28, 2021 Am J Geriatr Psychiatry. 2021 Aug 5:S1064-7481(21)00413-9. doi: 10.1016/j.jagp.2021.07.018. Online ahead of print.ABSTRACTOBJECTIVE: Administrative claims data are used to study the incidence and outcomes of dementia-related hallucinations, but the validity of International Classification of Diseases (ICD) codes for identifying dementia-related hallucinations is unknown.METHODS: We analyzed Medicare-linked survey data from 2 nationally representative studies of U.S. older adults (the National Health…
• Medicare Claims Data Underestimate Hallucinations in Older Adults With Dementia August 28, 2021 Am J Geriatr Psychiatry. 2021 Aug 5:S1064-7481(21)00413-9. doi: 10.1016/j.jagp.2021.07.018. Online ahead of print.ABSTRACTOBJECTIVE: Administrative claims data are used to study the incidence and outcomes of dementia-related hallucinations, but the validity of International Classification of Diseases (ICD) codes for identifying dementia-related hallucinations is unknown.METHODS: We analyzed Medicare-linked survey data from 2 nationally representative studies of U.S. older adults (the National Health…
• Medicare Claims Data Underestimate Hallucinations in Older Adults With Dementia August 28, 2021 Am J Geriatr Psychiatry. 2021 Aug 5:S1064-7481(21)00413-9. doi: 10.1016/j.jagp.2021.07.018. Online ahead of print.ABSTRACTOBJECTIVE: Administrative claims data are used to study the incidence and outcomes of dementia-related hallucinations, but the validity of International Classification of Diseases (ICD) codes for identifying dementia-related hallucinations is unknown.METHODS: We analyzed Medicare-linked survey data from 2 nationally representative studies of U.S. older adults (the National Health…
• Medicare Claims Data Underestimate Hallucinations in Older Adults With Dementia August 28, 2021 Am J Geriatr Psychiatry. 2021 Aug 5:S1064-7481(21)00413-9. doi: 10.1016/j.jagp.2021.07.018. Online ahead of print.ABSTRACTOBJECTIVE: Administrative claims data are used to study the incidence and outcomes of dementia-related hallucinations, but the validity of International Classification of Diseases (ICD) codes for identifying dementia-related hallucinations is unknown.METHODS: We analyzed Medicare-linked survey data from 2 nationally representative studies of U.S. older adults (the National Health…
• The role of attentional control over interference in minor hallucinations in Parkinson's disease August 20, 2022 Parkinsonism Relat Disord. 2022 Aug 13;102:101-107. doi: 10.1016/j.parkreldis.2022.07.009. Online ahead of print.ABSTRACTBACKGROUND: Minor hallucinations in Parkinson's disease are associated with connectivity changes in attentional networks and increased risk of structured hallucinations. However, the clinical translation of these abnormalities in attention processes is not well-defined, and commonly used neuropsychological tests are not able to detect significant deficits in Parkinson's disease patients…
• The role of attentional control over interference in minor hallucinations in Parkinson's disease August 20, 2022 Parkinsonism Relat Disord. 2022 Aug 13;102:101-107. doi: 10.1016/j.parkreldis.2022.07.009. Online ahead of print.ABSTRACTBACKGROUND: Minor hallucinations in Parkinson's disease are associated with connectivity changes in attentional networks and increased risk of structured hallucinations. However, the clinical translation of these abnormalities in attention processes is not well-defined, and commonly used neuropsychological tests are not able to detect significant deficits in Parkinson's disease patients…
• The role of attentional control over interference in minor hallucinations in Parkinson's disease August 20, 2022 Parkinsonism Relat Disord. 2022 Aug 13;102:101-107. doi: 10.1016/j.parkreldis.2022.07.009. Online ahead of print.ABSTRACTBACKGROUND: Minor hallucinations in Parkinson's disease are associated with connectivity changes in attentional networks and increased risk of structured hallucinations. However, the clinical translation of these abnormalities in attention processes is not well-defined, and commonly used neuropsychological tests are not able to detect significant deficits in Parkinson's disease patients…
• The role of attentional control over interference in minor hallucinations in Parkinson's disease August 20, 2022 Parkinsonism Relat Disord. 2022 Aug 13;102:101-107. doi: 10.1016/j.parkreldis.2022.07.009. Online ahead of print.ABSTRACTBACKGROUND: Minor hallucinations in Parkinson's disease are associated with connectivity changes in attentional networks and increased risk of structured hallucinations. However, the clinical translation of these abnormalities in attention processes is not well-defined, and commonly used neuropsychological tests are not able to detect significant deficits in Parkinson's disease patients…
• Almost 40% of people with Parkinson’s disease experience hallucinations, study finds October 28, 2021 Researchers in China have found that nearly four in 10 people with Parkinson’s disease experience minor hallucinations. The study analysed 262 people with Parkinson’s who visited the Affiliated Brain Hospital of Nanjing Medical University, China. Among these, 102 experienced minor hallucinations at a frequency that ranged from “daily to less than once a week”. The team also reported that 22.1%…
• Functional and structural brain network correlates of visual hallucinations in Lewy body dementia March 9, 2022 Brain. 2022 Mar 9:awac094. doi: 10.1093/brain/awac094. Online ahead of print.ABSTRACTVisual hallucinations are a common feature of Lewy body dementia. Previous studies have shown that visual hallucinations are highly specific in differentiating Lewy body dementia from Alzheimer's disease dementia and Alzheimer-Lewy body mixed pathology cases. Computational models propose that impairment of visual and attentional networks is aetiologically key to the manifestation…
• Functional and structural brain network correlates of visual hallucinations in Lewy body dementia March 9, 2022 Brain. 2022 Mar 9:awac094. doi: 10.1093/brain/awac094. Online ahead of print.ABSTRACTVisual hallucinations are a common feature of Lewy body dementia. Previous studies have shown that visual hallucinations are highly specific in differentiating Lewy body dementia from Alzheimer's disease dementia and Alzheimer-Lewy body mixed pathology cases. Computational models propose that impairment of visual and attentional networks is aetiologically key to the manifestation…
• The road ahead: 2022 January 20, 2022 # # # # The first post at the start of each year on the SoPD website tries to provide an overview of where things are in the search for ‘disease modifying’ therapies for Parkinson’s.  It is an exercise in managing expectations as well as discussing what research events are scheduled for the next year so that we can keep…
• Nuplazid Shows Sustained Easing of Psychosis in Patients in Phase 3 Trial June 8, 2020 Daily use of Nuplazid (pimavanserin) leads to strong and sustained reductions in the frequency and severity of hallucinations and delusions in people with Parkinson’s disease psychosis, according to data from a long-term extension study. These findings, “Improvement and Durability in SAPS-PD Assessment over 10 Weeks of Pimavanserin Treatment for Parkinson’s Disease Psychosis,” were presented at the at the 2020 American…
• Cerebellar correlates of visual hallucinations in Parkinson's disease and Charles Bonnet Syndrome. January 5, 2021 Related ArticlesCerebellar correlates of visual hallucinations in Parkinson's disease and Charles Bonnet Syndrome. Cortex. 2020 Dec 05;: Authors: Lawn T, Ffytche D Abstract Hallucinations, percepts in the absence of external stimuli, are a shared feature of eye-disease (Charles Bonnet Syndrome, CBS) and Parkinson's disease (PD) thought to arise through pathophysiologically distinct mechanisms: deafferentation and attentional network dysfunction respectively. Recent studies…