Pathological substrate of memory impairment in multiple system atrophy

Pathological substrate of memory impairment in multiple system atrophy
Neuropathol Appl Neurobiol. 2022 Jul 29:e12844. doi: 10.1111/nan.12844. Online ahead of print.ABSTRACTAIMS AND METHODS: Synaptic dysfunction in Parkinson's disease is caused by propagation of pathogenic α-synuclein between neurons. Previously, in multiple system atrophy (MSA), pathologically characterised by ectopic deposition of abnormal α-synuclein predominantly in oligodendrocytes, we demonstrated that the occurrence of memory impairment was associated with the number of α-synuclein-positive ... read more
Source: PubMedPublished on 2022-07-30By Yasuo Miki