Patterns of TDP-43 Deposition in Brains with LRRK2 G2019S Mutations

Patterns of TDP-43 Deposition in Brains with LRRK2 G2019S Mutations
Mov Disord. 2023 May 23. doi: 10.1002/mds.29449. Online ahead of print.ABSTRACTOBJECTIVE: To assess for TDP-43 deposits in brains with and without a LRRK2 G2019S mutation.BACKGROUND: LRRK2 G2019S mutations have been associated with parkinsonism and a wide range of pathological findings. There are no systematic studies examining the frequency and extent of TDP-43 deposits in neuropathological samples from LRRK2 G2019S carriers.METHODS: ... read more
Source: PubMedPublished on 2023-05-23By Julian Agin-Liebes