Perampanel Inhibits alpha-Synuclein Transmission in Parkinson’s Disease Models

Perampanel Inhibits alpha-Synuclein Transmission in Parkinson’s Disease Models
Mov Disord. 2021 Apr 4. doi: 10.1002/mds.28558. Online ahead of print.ABSTRACTBACKGROUND: The intercellular transmission of pathogenic proteins plays a key role in the clinicopathological progression of neurodegenerative diseases. Previous studies have demonstrated that this uptake and release process is regulated by neuronal activity.OBJECTIVE: The objective of this study was to examine the effect of perampanel, an antiepileptic drug, on α-synuclein ... read more
Source: PubMedPublished on 2021-04-04By Jun Ueda