Performance of αSynuclein RT-QuIC in relation to neuropathological staging of Lewy body disease

Performance of αSynuclein RT-QuIC in relation to neuropathological staging of Lewy body disease
Acta Neuropathol Commun. 2022 Jun 22;10(1):90. doi: 10.1186/s40478-022-01388-7.ABSTRACTCurrently, there is a need for diagnostic markers in Lewy body disorders (LBD). α-synuclein (αSyn) RT-QuIC has emerged as a promising assay to detect misfolded αSyn in clinically or neuropathologically established patients with various synucleinopathies. In this study, αSyn RT-QuIC was used to analyze lumbar CSF in a clinical cohort from the Swedish ... read more
Source: PubMedPublished on 2022-06-22By Sara Hall