Performance of αSynuclein RT-QuIC in relation to neuropathological staging of Lewy body disease

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• Performance of αSynuclein RT-QuIC in relation to neuropathological staging of Lewy body disease June 22, 2022 Acta Neuropathol Commun. 2022 Jun 22;10(1):90. doi: 10.1186/s40478-022-01388-7.ABSTRACTCurrently, there is a need for diagnostic markers in Lewy body disorders (LBD). α-synuclein (αSyn) RT-QuIC has emerged as a promising assay to detect misfolded αSyn in clinically or neuropathologically established patients with various synucleinopathies. In this study, αSyn RT-QuIC was used to analyze lumbar CSF in a clinical cohort from the Swedish…
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