PINK1 import regulation at a crossroad of mitochondrial fate.

PINK1 import regulation at a crossroad of mitochondrial fate.
PINK1 import regulation at a crossroad of mitochondrial fate. J Biochem. 2019 Sep 04;: Authors: Sekine S Abstract PTEN-induced kinase 1 (PINK1) is a mitochondrial kinase whose activity is tightly regulated by the mitochondrial health status. In response to mitochondrial damage, activated PINK1 can promote mitophagy, an autophagic elimination of damaged mitochondria, by cooperating with Parkin ubiquitin ligase. Loss-of-function of ... read more
Source: PubMedPublished on 2019-09-11