Polygenic risk prediction and SNCA haplotype analysis in a Latino Parkinson’s disease cohort

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• The road ahead: 2020 January 5, 2020 Here at the SoPD, we are primarily interested in disease modification for Parkinson’s. While there is a great deal of interesting research exploring the causes of the condition, novel symptomatic therapies, and other aspects of Parkinson’s, my focus is generally on the science seeking to slow, stop or reverse the condition. At the start of each year, it is a…
• Polygenic risk prediction and SNCA haplotype analysis in a Latino Parkinson's disease cohort August 2, 2022 Parkinsonism Relat Disord. 2022 Jun 18;102:7-15. doi: 10.1016/j.parkreldis.2022.06.010. Online ahead of print.ABSTRACTBACKGROUND: Large-scale Parkinson's disease (PD) genome-wide association studies (GWAS) have, until recently, only been conducted on subjects with European-ancestry. Consequently, polygenic risk scores (PRS) constructed using PD GWAS data are likely to be less predictive when applied to non-European cohorts.METHODS: Using GWAS data from the largest study to date,…
• Polygenic risk prediction and SNCA haplotype analysis in a Latino Parkinson's disease cohort August 2, 2022 Parkinsonism Relat Disord. 2022 Jun 18;102:7-15. doi: 10.1016/j.parkreldis.2022.06.010. Online ahead of print.ABSTRACTBACKGROUND: Large-scale Parkinson's disease (PD) genome-wide association studies (GWAS) have, until recently, only been conducted on subjects with European-ancestry. Consequently, polygenic risk scores (PRS) constructed using PD GWAS data are likely to be less predictive when applied to non-European cohorts.METHODS: Using GWAS data from the largest study to date,…
• Polygenic risk prediction and SNCA haplotype analysis in a Latino Parkinson's disease cohort August 2, 2022 Parkinsonism Relat Disord. 2022 Jun 18;102:7-15. doi: 10.1016/j.parkreldis.2022.06.010. Online ahead of print.ABSTRACTBACKGROUND: Large-scale Parkinson's disease (PD) genome-wide association studies (GWAS) have, until recently, only been conducted on subjects with European-ancestry. Consequently, polygenic risk scores (PRS) constructed using PD GWAS data are likely to be less predictive when applied to non-European cohorts.METHODS: Using GWAS data from the largest study to date,…
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