Polygenic risk prediction and SNCA haplotype analysis in a Latino Parkinson’s disease cohort

Polygenic risk prediction and SNCA haplotype analysis in a Latino Parkinson’s disease cohort
Parkinsonism Relat Disord. 2022 Jun 18;102:7-15. doi: 10.1016/j.parkreldis.2022.06.010. Online ahead of print.ABSTRACTBACKGROUND: Large-scale Parkinson's disease (PD) genome-wide association studies (GWAS) have, until recently, only been conducted on subjects with European-ancestry. Consequently, polygenic risk scores (PRS) constructed using PD GWAS data are likely to be less predictive when applied to non-European cohorts.METHODS: Using GWAS data from the largest study to date, ... read more
Source: PubMedPublished on 2022-08-02By Douglas P Loesch