Post-translational modifications of soluble α-synuclein regulate the amplification of pathological α-synuclein

Post-translational modifications of soluble α-synuclein regulate the amplification of pathological α-synuclein
Nat Neurosci. 2023 Jan 23. doi: 10.1038/s41593-022-01239-7. Online ahead of print.ABSTRACTCell-to-cell transmission and subsequent amplification of pathological proteins promote neurodegenerative disease progression. Most research on this has focused on pathological protein seeds, but how their normal counterparts, which are converted to pathological forms during transmission, regulate transmission is less understood. Here we show in cultured cells that phosphorylation of soluble, ... read more
Source: PubMedPublished on 2023-01-23By Shujing Zhang